Calpain cleavage regulates the protein stability of p73

The function of p73, a transcription factor belonging to the p53 family, is finely regulated by its steady-state protein stability. p73 protein degradation/stabilization can be regulated by mechanisms in part dependent on the ubiquitin proteasome system (UPS): (i) Itch/NEDD4-like UPS degradation, (i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-08, Vol.333 (3), p.954-960
Hauptverfasser:	Munarriz, Eliana, Bano, Daniele, Sayan, A. Emre, Rossi, Mario, Melino, Gerry, Nicotera, Pierluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Base Sequence Calcium Calpain - chemistry Calpain - metabolism Calpains Calpastatin Cell Death Cell Line, Tumor DNA Primers DNA-Binding Proteins - metabolism Electrophoresis, Polyacrylamide Gel Genes, Tumor Suppressor Humans Hydrolysis Neural development Nuclear Proteins - metabolism p53 p73 Plasmids Protein degradation Protein Isoforms - metabolism Protein stability TCR-apoptosis Tumor Protein p73 Tumor Suppressor Proteins
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