Enhanced dorsolateral periaqueductal gray activity counteracts the anxiolytic response to midazolam on the elevated plus-maze Trial 2 in rats

Rodents previously (Trial 1) experienced in the elevated plus-maze (EPM) apparatus no longer respond to anxiolytic-like drugs during retesting (Trial 2). In view of the fact that the dorsolateral periaqueductal gray (dlPAG) modulates fear/anxiety-like behavior, the present study sought to determine...

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Veröffentlicht in:	Behavioural brain research 2005-07, Vol.162 (1), p.99-107
Hauptverfasser:	Bertoglio, Leandro José, Anzini, Cláudia, Lino-de-Oliveira, Cilene, Carobrez, Antônio Pádua
Format:	Artikel
Sprache:	eng
Schlagworte:	Affectivity. Emotion Anesthetics, Local - pharmacology Animals Anti-Anxiety Agents - administration & dosage Anxiety Behavior, Animal - drug effects Benzodiazepine Biological and medical sciences Drug Administration Routes Drug Administration Schedule Drug Interactions Elevated plus-maze Fear Fundamental and applied biological sciences. Psychology Lidocaine - pharmacology Male Maze Learning - drug effects Midazolam - administration & dosage One-trial tolerance Periaqueductal gray Periaqueductal Gray - drug effects Periaqueductal Gray - physiology Personality. Affectivity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar
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