Solution structure of the all l- and d-amino acid-substituted mucin 2 epitope peptides

High-molecular-weight mucin 2 (MUC2) glycoproteins show an aberrant glycosylation pattern when expressed in human colon carcinoma: the oligosaccharide chains are shorter and some are missing. In our ongoing effort of MUC2 vaccine development, we have solved the NMR structure of the all l-amino acid...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-07, Vol.358 (3), p.739-742
Hauptverfasser:	Toke, Orsolya, Tugyi, Regina, Uray, Katalin, Hudecz, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Antibody binding Cell Line, Tumor Colonic Neoplasms - metabolism d-Amino acid substitution Enzymatic stability Epitope Epitopes - chemistry Glycoproteins - chemistry Glycosylation Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Molecular Conformation MUC2 Mucin Mucin-2 Mucins - chemistry NMR spectroscopy Peptides - chemistry Protein Conformation Synthetic peptides Synthetic vaccines Vaccines, Synthetic - chemistry β-Turn conformation
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