Transient overexpression of the 5-HT sub(1) sub(A) receptor impairs water-maze but not hole-board performance

Transient overexpression of the 5-HT sub(1) sub(A) receptor impairs water-maze but not hole-board performance

Previously, we showed that mice that overexpress the 5-HT sub(1) sub(A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT sub(1) sub(A...

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Veröffentlicht in:Neurobiology of learning and memory 2005-07, Vol.84 (1), p.57-68
Hauptverfasser: Bert, B, Dere, E, Wilhelmi, N, Kusserow, H, Theuring, F, Huston, J P, Fink, H
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container_end_page 68
container_issue 1
container_start_page 57
container_title Neurobiology of learning and memory
container_volume 84
creator Bert, B
Dere, E
Wilhelmi, N
Kusserow, H
Theuring, F
Huston, J P
Fink, H
description Previously, we showed that mice that overexpress the 5-HT sub(1) sub(A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT sub(1) sub(A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT sub(1) sub(A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.
doi_str_mv 10.1016/j.nlm.2005.03.005
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title Transient overexpression of the 5-HT sub(1) sub(A) receptor impairs water-maze but not hole-board performance
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