Sensing of invading pathogens by GBPs: At the crossroads between cell‐autonomous and innate immunity

Guanylate‐binding proteins (GBPs) are conserved family of IFN‐inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with...

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Veröffentlicht in:Journal of leukocyte biology 2018-10, Vol.104 (4), p.729-735
Hauptverfasser: Santos, José Carlos, Broz, Petr
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Sprache:eng
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