Sequential treatment with sildenafil and riociguat in patients with persistent or inoperable chronic thromboembolic pulmonary hypertension improves functional class and pulmonary hemodynamics

This study evaluated the incremental effect of riociguat on pulmonary hemodynamics in patients with inoperative or persistent chronic thromboembolic pulmonary hypertension (CTEPH) treated previously with sildenafil. The retrospective study included 28 patients diagnosed with CTEPH who were ineligibl...

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Veröffentlicht in:	International journal of cardiology 2018-10, Vol.269, p.283-288
Hauptverfasser:	Darocha, Szymon, Banaszkiewicz, Marta, Pietrasik, Arkadiusz, Piłka, Michał, Florczyk, Michał, Wieteska, Maria, Dobosiewicz, Anna, Szmit, Sebastian, Torbicki, Adam, Kurzyna, Marcin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Chronic Disease Chronic thromboembolic pulmonary hypertension Drug Substitution - methods Enzyme Activators - administration & dosage Female Hemodynamics Hemodynamics - drug effects Hemodynamics - physiology Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology Lung - drug effects Lung - physiology Male Middle Aged Pulmonary Embolism - diagnosis Pulmonary Embolism - drug therapy Pulmonary Embolism - physiopathology Pyrazoles - administration & dosage Pyrimidines - administration & dosage Retrospective Studies Riociguat Sequential therapy Sildenafil Sildenafil Citrate - administration & dosage Treatment Outcome Vasodilator Agents - administration & dosage
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