ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx

Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn2+) homeostasis in monocyte adhesion and recruitment. By comparing the expression levels of Zn2+ transporters between non-adhering and adhering monocytes, we fou...

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Veröffentlicht in:	International immunopharmacology 2018-09, Vol.62, p.203-211
Hauptverfasser:	Cheng, Gong, Chang, Feng-jun, You, Peng-Hua, Lin, Jing, Huang, Xiao-Yan, Wu, Hao-Yu, Yan, Li, Deng, Ji-Zhao, You, Hong-Jun, Sun, Chao-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Aorta - metabolism Aorta - pathology Apolipoprotein E Apolipoproteins E - genetics Arteries Arteriosclerosis Atherosclerosis Cadmium Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Adhesion - genetics Cell Line Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Disease Models, Animal Homeostasis Inflammation Iron Lesions Mice, Inbred C57BL Mice, Knockout Monocyte Monocytes Monocytes - metabolism Monocytes - pathology Supplements Up-Regulation Zinc Zinc - metabolism ZIP8
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