Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study
Summary There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, wi...
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| Veröffentlicht in: | Osteoporosis international 2018-09, Vol.29 (9), p.2011-2020 |
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| creator | Choi, C. K. Kweon, S. -S. Lee, Y. -H. Nam, H. -S. Park, K. -S. Ryu, S. -Y. Choi, S. -W. Kim, S. A. Shin, M. -H. |
| description | Summary
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Introduction
Bone mineral density (BMD) is reported inversely associated with mortality. Although some previous studies provided evidence for nonlinear associations, these were not adequately assessed in most previous works.
Methods
We evaluated the nonlinear relationship between BMD and mortality in Asians. Our study involved 8629 participants in the Dong-gu study from 2007 to 2010. Cox proportional hazard regression was used to calculate hazard ratios (HRs) according to BMD categories after adjusting for potential confounders. During a follow-up of 6.7 ± 1.4 years, 712 participants died.
Results
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In males, compared with the 75th to 95th percentile group, the 97.5th percentile group. In females, compared with that in the 75th to 95th percentile group, the HR was 2.33 (95% CI 1.24, 4.39) in the |
| doi_str_mv | 10.1007/s00198-018-4386-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2071564062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2071564062</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-1f32f28574f92b9fbbb05f86bb396a9b3fbabce69539d194bd7f9a3bd38934e33</originalsourceid><addsrcrecordid>eNp1kF9LwzAUxYMobk4_gC8S8MWXaNK0aeObzL8w9EXBFwlJm8yOLplJi2yf3pROBcGnC_f8zrmXA8AxwecE4_wiYEx4gTApUEoLhjY7YExSSlHCWbYLxpjTHPGUvI7AQQgLHD2c5_tgRKMxJVkxBm-Pzja11dJDGYIra9nWzkKl20-t43RWw2XUvWxgpW2o2zWUtoKyaVApuxBV51vZxP0lbN81vHZ2juYdDG1XrQ_BnpFN0EfbOQEvtzfP03s0e7p7mF7NUEnzpEXE0MQkRZanhieKG6UUzkzBlKKcSa6oUVKVmvGM8orwVFW54ZKqihacpprSCTgbclfefXQ6tGJZh1I3jbTadUEkOCcZSzFLInr6B124ztv4XU9hRlhW9BQZqNK7ELw2YuXrpfRrQbDouxdD9yJ2L_ruxSZ6TrbJnVrq6sfxXXYEkgEIUbJz7X9P_5_6Be4zkDo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070616582</pqid></control><display><type>article</type><title>Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Choi, C. K. ; Kweon, S. -S. ; Lee, Y. -H. ; Nam, H. -S. ; Park, K. -S. ; Ryu, S. -Y. ; Choi, S. -W. ; Kim, S. A. ; Shin, M. -H.</creator><creatorcontrib>Choi, C. K. ; Kweon, S. -S. ; Lee, Y. -H. ; Nam, H. -S. ; Park, K. -S. ; Ryu, S. -Y. ; Choi, S. -W. ; Kim, S. A. ; Shin, M. -H.</creatorcontrib><description>Summary
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Introduction
Bone mineral density (BMD) is reported inversely associated with mortality. Although some previous studies provided evidence for nonlinear associations, these were not adequately assessed in most previous works.
Methods
We evaluated the nonlinear relationship between BMD and mortality in Asians. Our study involved 8629 participants in the Dong-gu study from 2007 to 2010. Cox proportional hazard regression was used to calculate hazard ratios (HRs) according to BMD categories after adjusting for potential confounders. During a follow-up of 6.7 ± 1.4 years, 712 participants died.
Results
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In males, compared with the 75th to 95th percentile group, the < 2.5th percentile group had a 3.89 (95% CI 2.41–6.28)-fold higher risk and the 2.5th to 5th percentile group had a 2.51 (95% CI 1.25–5.04)-fold higher risk. The HR was 2.51 (95% CI 1.25, 5.04) in the > 97.5th percentile group. In females, compared with that in the 75th to 95th percentile group, the HR was 2.33 (95% CI 1.24, 4.39) in the < 2.5th percentile group. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Conclusion
In conclusion, this study shows that the association between BMD and mortality varies by gender and that high and low BMD are predictors of all-cause mortality in males.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-018-4386-z</identifier><identifier>PMID: 30014158</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon - methods ; Aged ; Aged, 80 and over ; Bone density ; Bone Density - physiology ; Bone mineral density ; Cohort analysis ; Endocrinology ; Female ; Females ; Follow-Up Studies ; Health risk assessment ; Hip ; Hip Joint - physiology ; Humans ; Lumbar Vertebrae - physiology ; Male ; Males ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Original Article ; Orthopedics ; Osteoporosis ; Osteoporosis - mortality ; Osteoporosis - physiopathology ; Republic of Korea - epidemiology ; Rheumatology ; Sex Factors ; Spine (lumbar)</subject><ispartof>Osteoporosis international, 2018-09, Vol.29 (9), p.2011-2020</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2018</rights><rights>Osteoporosis International is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1f32f28574f92b9fbbb05f86bb396a9b3fbabce69539d194bd7f9a3bd38934e33</citedby><cites>FETCH-LOGICAL-c372t-1f32f28574f92b9fbbb05f86bb396a9b3fbabce69539d194bd7f9a3bd38934e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-018-4386-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-018-4386-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30014158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, C. K.</creatorcontrib><creatorcontrib>Kweon, S. -S.</creatorcontrib><creatorcontrib>Lee, Y. -H.</creatorcontrib><creatorcontrib>Nam, H. -S.</creatorcontrib><creatorcontrib>Park, K. -S.</creatorcontrib><creatorcontrib>Ryu, S. -Y.</creatorcontrib><creatorcontrib>Choi, S. -W.</creatorcontrib><creatorcontrib>Kim, S. A.</creatorcontrib><creatorcontrib>Shin, M. -H.</creatorcontrib><title>Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Introduction
Bone mineral density (BMD) is reported inversely associated with mortality. Although some previous studies provided evidence for nonlinear associations, these were not adequately assessed in most previous works.
Methods
We evaluated the nonlinear relationship between BMD and mortality in Asians. Our study involved 8629 participants in the Dong-gu study from 2007 to 2010. Cox proportional hazard regression was used to calculate hazard ratios (HRs) according to BMD categories after adjusting for potential confounders. During a follow-up of 6.7 ± 1.4 years, 712 participants died.
Results
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In males, compared with the 75th to 95th percentile group, the < 2.5th percentile group had a 3.89 (95% CI 2.41–6.28)-fold higher risk and the 2.5th to 5th percentile group had a 2.51 (95% CI 1.25–5.04)-fold higher risk. The HR was 2.51 (95% CI 1.25, 5.04) in the > 97.5th percentile group. In females, compared with that in the 75th to 95th percentile group, the HR was 2.33 (95% CI 1.24, 4.39) in the < 2.5th percentile group. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Conclusion
In conclusion, this study shows that the association between BMD and mortality varies by gender and that high and low BMD are predictors of all-cause mortality in males.</description><subject>Absorptiometry, Photon - methods</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bone mineral density</subject><subject>Cohort analysis</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>Hip</subject><subject>Hip Joint - physiology</subject><subject>Humans</subject><subject>Lumbar Vertebrae - physiology</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis - mortality</subject><subject>Osteoporosis - physiopathology</subject><subject>Republic of Korea - epidemiology</subject><subject>Rheumatology</subject><subject>Sex Factors</subject><subject>Spine (lumbar)</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kF9LwzAUxYMobk4_gC8S8MWXaNK0aeObzL8w9EXBFwlJm8yOLplJi2yf3pROBcGnC_f8zrmXA8AxwecE4_wiYEx4gTApUEoLhjY7YExSSlHCWbYLxpjTHPGUvI7AQQgLHD2c5_tgRKMxJVkxBm-Pzja11dJDGYIra9nWzkKl20-t43RWw2XUvWxgpW2o2zWUtoKyaVApuxBV51vZxP0lbN81vHZ2juYdDG1XrQ_BnpFN0EfbOQEvtzfP03s0e7p7mF7NUEnzpEXE0MQkRZanhieKG6UUzkzBlKKcSa6oUVKVmvGM8orwVFW54ZKqihacpprSCTgbclfefXQ6tGJZh1I3jbTadUEkOCcZSzFLInr6B124ztv4XU9hRlhW9BQZqNK7ELw2YuXrpfRrQbDouxdD9yJ2L_ruxSZ6TrbJnVrq6sfxXXYEkgEIUbJz7X9P_5_6Be4zkDo</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Choi, C. K.</creator><creator>Kweon, S. -S.</creator><creator>Lee, Y. -H.</creator><creator>Nam, H. -S.</creator><creator>Park, K. -S.</creator><creator>Ryu, S. -Y.</creator><creator>Choi, S. -W.</creator><creator>Kim, S. A.</creator><creator>Shin, M. -H.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study</title><author>Choi, C. K. ; Kweon, S. -S. ; Lee, Y. -H. ; Nam, H. -S. ; Park, K. -S. ; Ryu, S. -Y. ; Choi, S. -W. ; Kim, S. A. ; Shin, M. -H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1f32f28574f92b9fbbb05f86bb396a9b3fbabce69539d194bd7f9a3bd38934e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Bone mineral density</topic><topic>Cohort analysis</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>Hip</topic><topic>Hip Joint - physiology</topic><topic>Humans</topic><topic>Lumbar Vertebrae - physiology</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis - mortality</topic><topic>Osteoporosis - physiopathology</topic><topic>Republic of Korea - epidemiology</topic><topic>Rheumatology</topic><topic>Sex Factors</topic><topic>Spine (lumbar)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, C. K.</creatorcontrib><creatorcontrib>Kweon, S. -S.</creatorcontrib><creatorcontrib>Lee, Y. -H.</creatorcontrib><creatorcontrib>Nam, H. -S.</creatorcontrib><creatorcontrib>Park, K. -S.</creatorcontrib><creatorcontrib>Ryu, S. -Y.</creatorcontrib><creatorcontrib>Choi, S. -W.</creatorcontrib><creatorcontrib>Kim, S. A.</creatorcontrib><creatorcontrib>Shin, M. -H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, C. K.</au><au>Kweon, S. -S.</au><au>Lee, Y. -H.</au><au>Nam, H. -S.</au><au>Park, K. -S.</au><au>Ryu, S. -Y.</au><au>Choi, S. -W.</au><au>Kim, S. A.</au><au>Shin, M. -H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>29</volume><issue>9</issue><spage>2011</spage><epage>2020</epage><pages>2011-2020</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Introduction
Bone mineral density (BMD) is reported inversely associated with mortality. Although some previous studies provided evidence for nonlinear associations, these were not adequately assessed in most previous works.
Methods
We evaluated the nonlinear relationship between BMD and mortality in Asians. Our study involved 8629 participants in the Dong-gu study from 2007 to 2010. Cox proportional hazard regression was used to calculate hazard ratios (HRs) according to BMD categories after adjusting for potential confounders. During a follow-up of 6.7 ± 1.4 years, 712 participants died.
Results
There was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In males, compared with the 75th to 95th percentile group, the < 2.5th percentile group had a 3.89 (95% CI 2.41–6.28)-fold higher risk and the 2.5th to 5th percentile group had a 2.51 (95% CI 1.25–5.04)-fold higher risk. The HR was 2.51 (95% CI 1.25, 5.04) in the > 97.5th percentile group. In females, compared with that in the 75th to 95th percentile group, the HR was 2.33 (95% CI 1.24, 4.39) in the < 2.5th percentile group. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.
Conclusion
In conclusion, this study shows that the association between BMD and mortality varies by gender and that high and low BMD are predictors of all-cause mortality in males.</abstract><cop>London</cop><pub>Springer London</pub><pmid>30014158</pmid><doi>10.1007/s00198-018-4386-z</doi><tpages>10</tpages></addata></record> |
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| subjects | Absorptiometry, Photon - methods Aged Aged, 80 and over Bone density Bone Density - physiology Bone mineral density Cohort analysis Endocrinology Female Females Follow-Up Studies Health risk assessment Hip Hip Joint - physiology Humans Lumbar Vertebrae - physiology Male Males Medicine Medicine & Public Health Middle Aged Mortality Original Article Orthopedics Osteoporosis Osteoporosis - mortality Osteoporosis - physiopathology Republic of Korea - epidemiology Rheumatology Sex Factors Spine (lumbar) |
| title | Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study |
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