Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report
We report a case of intracranial germ cell tumor that showed pathological changes from neurohypophyseal germinoma to mixed germ cell tumors consisting exclusively of undifferentiated sarcomatous component after radiochemotherapy. Three surgical specimens and autopsied brain from the patient were his...
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| Veröffentlicht in: | Brain tumor pathology 2006-10, Vol.23 (2), p.83-89 |
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| container_title | Brain tumor pathology |
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| creator | Kamitani, Hideki Miyata, Hajime Ishibashi, Minako Kurosaki, Masamichi Mizushima, Minoru Akatsuka, Keiichi Ohama, Eisaku Watanabe, Takashi |
| description | We report a case of intracranial germ cell tumor that showed pathological changes from neurohypophyseal germinoma to mixed germ cell tumors consisting exclusively of undifferentiated sarcomatous component after radiochemotherapy. Three surgical specimens and autopsied brain from the patient were histologically examined. An initial specimen from the neurohypophyseal tumor was diagnosed as germinoma with a two-cell pattern. Five years later, after repeated radiochemotherapy, the second specimen resected from the right temporal lobe showed mixed germ cell tumors consisting of the three components of germinoma, choriocarcinoma, and immature teratoma. Six months later after intensive radiotherapy, the right temporal tumor recurred and was surgically removed. The histological diagnosis was mixed germ cell tumors with abundant immature teratoma component. The patient died of uncontrollable tumor growth with repeated intratumoral hemorrhages. The autopsied brain showed sarcoma with angionecrosis. This pathological alteration indicated an increase in the sarcomatous component after undergoing various treatments. We discuss the histological changes of intracranial germ cell tumor modified by treatment. |
| doi_str_mv | 10.1007/s10014-006-0205-x |
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Three surgical specimens and autopsied brain from the patient were histologically examined. An initial specimen from the neurohypophyseal tumor was diagnosed as germinoma with a two-cell pattern. Five years later, after repeated radiochemotherapy, the second specimen resected from the right temporal lobe showed mixed germ cell tumors consisting of the three components of germinoma, choriocarcinoma, and immature teratoma. Six months later after intensive radiotherapy, the right temporal tumor recurred and was surgically removed. The histological diagnosis was mixed germ cell tumors with abundant immature teratoma component. The patient died of uncontrollable tumor growth with repeated intratumoral hemorrhages. The autopsied brain showed sarcoma with angionecrosis. This pathological alteration indicated an increase in the sarcomatous component after undergoing various treatments. 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Three surgical specimens and autopsied brain from the patient were histologically examined. An initial specimen from the neurohypophyseal tumor was diagnosed as germinoma with a two-cell pattern. Five years later, after repeated radiochemotherapy, the second specimen resected from the right temporal lobe showed mixed germ cell tumors consisting of the three components of germinoma, choriocarcinoma, and immature teratoma. Six months later after intensive radiotherapy, the right temporal tumor recurred and was surgically removed. The histological diagnosis was mixed germ cell tumors with abundant immature teratoma component. The patient died of uncontrollable tumor growth with repeated intratumoral hemorrhages. The autopsied brain showed sarcoma with angionecrosis. This pathological alteration indicated an increase in the sarcomatous component after undergoing various treatments. We discuss the histological changes of intracranial germ cell tumor modified by treatment.</description><subject>Adolescent</subject><subject>Brain Neoplasms - pathology</subject><subject>Choriocarcinoma - pathology</subject><subject>Combined Modality Therapy</subject><subject>Fatal Outcome</subject><subject>Germinoma - pathology</subject><subject>Humans</subject><subject>Intracranial Hemorrhages - etiology</subject><subject>Intracranial Hemorrhages - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>Paraffin Embedding</subject><subject>Pituitary Gland, Posterior - pathology</subject><subject>Pituitary Neoplasms - drug therapy</subject><subject>Pituitary Neoplasms - radiotherapy</subject><subject>Sarcoma - pathology</subject><subject>Temporal Lobe - pathology</subject><subject>Teratoma - pathology</subject><subject>Tissue Fixation</subject><subject>Tumors</subject><issn>1433-7398</issn><issn>1861-387X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkcFq3DAQhkVoSdK0D5BLERRyczsj2Ws5txCatpCSSwK5Cdkexw625Uoy3X2PPnBn2YVCL9Lw882vGf1CXCJ8RoDyS-QT8wxgk4GCItueiHM0G8y0KZ_fcJ1rnZW6MmfiXYyvAHkOJZ6KMzRQFajyc_Hn57ClVr5QmGRD4yjTOvkQ5e8h9dLV69y6OcnoQuMnl_waJReLn4nVYZapJ5mIheBGOfqapOsSBRlcO_imp8kzEdyyk76TM63B97vFL_0uEjfsXx1mNr6WTjYukgzEVum9eNu5MdKH430hnu6-Pt5-z-4fvv24vbnPGm1UyopOqWrjFO_ftl1HSLl2ta6xLqCtgKHGVXWtdLlpodDYoTKApmHBFI5IX4irg-8S_K-VYrLTEPe_4GbiVa2CEipAZPDTf-CrX8PMs1lVYVmVRW40U3igmuBjDNTZJQyTCzuLYPeB2UNglge2-8Dslns-Hp3XeqL2X8cxIf0Xtb-Ukg</recordid><startdate>200610</startdate><enddate>200610</enddate><creator>Kamitani, Hideki</creator><creator>Miyata, Hajime</creator><creator>Ishibashi, Minako</creator><creator>Kurosaki, Masamichi</creator><creator>Mizushima, Minoru</creator><creator>Akatsuka, Keiichi</creator><creator>Ohama, Eisaku</creator><creator>Watanabe, Takashi</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7TK</scope></search><sort><creationdate>200610</creationdate><title>Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report</title><author>Kamitani, Hideki ; 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Three surgical specimens and autopsied brain from the patient were histologically examined. An initial specimen from the neurohypophyseal tumor was diagnosed as germinoma with a two-cell pattern. Five years later, after repeated radiochemotherapy, the second specimen resected from the right temporal lobe showed mixed germ cell tumors consisting of the three components of germinoma, choriocarcinoma, and immature teratoma. Six months later after intensive radiotherapy, the right temporal tumor recurred and was surgically removed. The histological diagnosis was mixed germ cell tumors with abundant immature teratoma component. The patient died of uncontrollable tumor growth with repeated intratumoral hemorrhages. The autopsied brain showed sarcoma with angionecrosis. This pathological alteration indicated an increase in the sarcomatous component after undergoing various treatments. We discuss the histological changes of intracranial germ cell tumor modified by treatment.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>18095124</pmid><doi>10.1007/s10014-006-0205-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Brain tumor pathology, 2006-10, Vol.23 (2), p.83-89 |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Adolescent Brain Neoplasms - pathology Choriocarcinoma - pathology Combined Modality Therapy Fatal Outcome Germinoma - pathology Humans Intracranial Hemorrhages - etiology Intracranial Hemorrhages - pathology Magnetic Resonance Imaging Male Neoplasms, Germ Cell and Embryonal - pathology Paraffin Embedding Pituitary Gland, Posterior - pathology Pituitary Neoplasms - drug therapy Pituitary Neoplasms - radiotherapy Sarcoma - pathology Temporal Lobe - pathology Teratoma - pathology Tissue Fixation Tumors |
| title | Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report |
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