A positive correlation between blood glucose level and bone mineral density in Taiwan
Summary This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition,...
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| Veröffentlicht in: | Archives of osteoporosis 2018-07, Vol.13 (1), p.78-78, Article 78 |
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| creator | Li, Kun-Hong Liu, Yen-Tze Yang, Yu-Wen Lin, Ying-Li Hung, Min-Ling Lin, I-Ching |
| description | Summary
This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood sugar and HbA1c.
Purpose
This study was undertaken to assess the effect of blood glucose on BMD and possible interactions with age, sex, and BMI in a Taiwanese population.
Patients and methods
This study was a retrospective cross-sectional study using data from the Health Examination Database of Changhua Christian Hospital. Data on BMD of the lumbar spine and femoral neck were obtained by dual X-ray absorptiometry (DXA), and other relevant clinical and laboratory data were recorded.
Results
The type 2 diabetes (T2DM) group had a higher BMD than the controls. When comparing the prevalence of osteoporosis between subjects by glucose and HbA1c level, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c. In addition, the BMD of the lumbar spine and femoral neck was higher in the T2DM group than in the controls. Osteoporosis was negatively associated with DM, BMI, and drinking, but positively associated with age, female gender, previous fracture history, and other diseases of the musculoskeletal system and connective tissue. The association between diabetes and osteoporosis remained statistically significant after adjusting for the above factors. T2DM was associated with lower odds of osteoporosis in both obese (OR = 0.77) and non-obese (OR = 0.63) (
p
for interaction = 0.555).
Conclusions
Both obese and non-obese people with T2DM had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c. |
| doi_str_mv | 10.1007/s11657-018-0494-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2070810208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070810208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-ef3a7596e7542e14fa142518c4c946bfc7cdbaa22a031c93c350589b5fe502253</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlZ_gBfJ0cvq5Gs_jqX4BQUveg7Z7KxsSZOa7Lb037vS2qOnGZjnfWEeQm4ZPDCA4jExlqsiA1ZmICuZVWdkysqcZ0IxeX7aOZ-Qq5RWADkwlV-SiQCASgiYks853YTU9d0WqQ0xojN9Fzytsd8hjtOF0NAvN9iQkDrcoqPGN7QOHum68xiNow36sWJPO08_TLcz_ppctMYlvDnOGfl8fvpYvGbL95e3xXyZWSFln2ErTKGqHAslOTLZGia5YqWVtpJ53drCNrUxnBsQzFbCCgWqrGrVogLOlZiR-0PvJobvAVOv112y6JzxGIakORRQMuBQjig7oDaGlCK2ehO7tYl7zUD_2tQHm3q0qX9t6mrM3B3rh3qNzSnxp28E-AFI48l_YdSrMEQ_vvxP6w9_8H9z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070810208</pqid></control><display><type>article</type><title>A positive correlation between blood glucose level and bone mineral density in Taiwan</title><source>SpringerLink Journals</source><creator>Li, Kun-Hong ; Liu, Yen-Tze ; Yang, Yu-Wen ; Lin, Ying-Li ; Hung, Min-Ling ; Lin, I-Ching</creator><creatorcontrib>Li, Kun-Hong ; Liu, Yen-Tze ; Yang, Yu-Wen ; Lin, Ying-Li ; Hung, Min-Ling ; Lin, I-Ching</creatorcontrib><description>Summary
This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood sugar and HbA1c.
Purpose
This study was undertaken to assess the effect of blood glucose on BMD and possible interactions with age, sex, and BMI in a Taiwanese population.
Patients and methods
This study was a retrospective cross-sectional study using data from the Health Examination Database of Changhua Christian Hospital. Data on BMD of the lumbar spine and femoral neck were obtained by dual X-ray absorptiometry (DXA), and other relevant clinical and laboratory data were recorded.
Results
The type 2 diabetes (T2DM) group had a higher BMD than the controls. When comparing the prevalence of osteoporosis between subjects by glucose and HbA1c level, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c. In addition, the BMD of the lumbar spine and femoral neck was higher in the T2DM group than in the controls. Osteoporosis was negatively associated with DM, BMI, and drinking, but positively associated with age, female gender, previous fracture history, and other diseases of the musculoskeletal system and connective tissue. The association between diabetes and osteoporosis remained statistically significant after adjusting for the above factors. T2DM was associated with lower odds of osteoporosis in both obese (OR = 0.77) and non-obese (OR = 0.63) (
p
for interaction = 0.555).
Conclusions
Both obese and non-obese people with T2DM had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c.</description><identifier>ISSN: 1862-3522</identifier><identifier>EISSN: 1862-3514</identifier><identifier>DOI: 10.1007/s11657-018-0494-9</identifier><identifier>PMID: 30009330</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Endocrinology ; Medicine ; Medicine & Public Health ; Original Article ; Orthopedics</subject><ispartof>Archives of osteoporosis, 2018-07, Vol.13 (1), p.78-78, Article 78</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-ef3a7596e7542e14fa142518c4c946bfc7cdbaa22a031c93c350589b5fe502253</citedby><cites>FETCH-LOGICAL-c344t-ef3a7596e7542e14fa142518c4c946bfc7cdbaa22a031c93c350589b5fe502253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11657-018-0494-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11657-018-0494-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30009330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Kun-Hong</creatorcontrib><creatorcontrib>Liu, Yen-Tze</creatorcontrib><creatorcontrib>Yang, Yu-Wen</creatorcontrib><creatorcontrib>Lin, Ying-Li</creatorcontrib><creatorcontrib>Hung, Min-Ling</creatorcontrib><creatorcontrib>Lin, I-Ching</creatorcontrib><title>A positive correlation between blood glucose level and bone mineral density in Taiwan</title><title>Archives of osteoporosis</title><addtitle>Arch Osteoporos</addtitle><addtitle>Arch Osteoporos</addtitle><description>Summary
This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood sugar and HbA1c.
Purpose
This study was undertaken to assess the effect of blood glucose on BMD and possible interactions with age, sex, and BMI in a Taiwanese population.
Patients and methods
This study was a retrospective cross-sectional study using data from the Health Examination Database of Changhua Christian Hospital. Data on BMD of the lumbar spine and femoral neck were obtained by dual X-ray absorptiometry (DXA), and other relevant clinical and laboratory data were recorded.
Results
The type 2 diabetes (T2DM) group had a higher BMD than the controls. When comparing the prevalence of osteoporosis between subjects by glucose and HbA1c level, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c. In addition, the BMD of the lumbar spine and femoral neck was higher in the T2DM group than in the controls. Osteoporosis was negatively associated with DM, BMI, and drinking, but positively associated with age, female gender, previous fracture history, and other diseases of the musculoskeletal system and connective tissue. The association between diabetes and osteoporosis remained statistically significant after adjusting for the above factors. T2DM was associated with lower odds of osteoporosis in both obese (OR = 0.77) and non-obese (OR = 0.63) (
p
for interaction = 0.555).
Conclusions
Both obese and non-obese people with T2DM had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c.</description><subject>Endocrinology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Orthopedics</subject><issn>1862-3522</issn><issn>1862-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlZ_gBfJ0cvq5Gs_jqX4BQUveg7Z7KxsSZOa7Lb037vS2qOnGZjnfWEeQm4ZPDCA4jExlqsiA1ZmICuZVWdkysqcZ0IxeX7aOZ-Qq5RWADkwlV-SiQCASgiYks853YTU9d0WqQ0xojN9Fzytsd8hjtOF0NAvN9iQkDrcoqPGN7QOHum68xiNow36sWJPO08_TLcz_ppctMYlvDnOGfl8fvpYvGbL95e3xXyZWSFln2ErTKGqHAslOTLZGia5YqWVtpJ53drCNrUxnBsQzFbCCgWqrGrVogLOlZiR-0PvJobvAVOv112y6JzxGIakORRQMuBQjig7oDaGlCK2ehO7tYl7zUD_2tQHm3q0qX9t6mrM3B3rh3qNzSnxp28E-AFI48l_YdSrMEQ_vvxP6w9_8H9z</recordid><startdate>20180716</startdate><enddate>20180716</enddate><creator>Li, Kun-Hong</creator><creator>Liu, Yen-Tze</creator><creator>Yang, Yu-Wen</creator><creator>Lin, Ying-Li</creator><creator>Hung, Min-Ling</creator><creator>Lin, I-Ching</creator><general>Springer London</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180716</creationdate><title>A positive correlation between blood glucose level and bone mineral density in Taiwan</title><author>Li, Kun-Hong ; Liu, Yen-Tze ; Yang, Yu-Wen ; Lin, Ying-Li ; Hung, Min-Ling ; Lin, I-Ching</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-ef3a7596e7542e14fa142518c4c946bfc7cdbaa22a031c93c350589b5fe502253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Endocrinology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Orthopedics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Kun-Hong</creatorcontrib><creatorcontrib>Liu, Yen-Tze</creatorcontrib><creatorcontrib>Yang, Yu-Wen</creatorcontrib><creatorcontrib>Lin, Ying-Li</creatorcontrib><creatorcontrib>Hung, Min-Ling</creatorcontrib><creatorcontrib>Lin, I-Ching</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of osteoporosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Kun-Hong</au><au>Liu, Yen-Tze</au><au>Yang, Yu-Wen</au><au>Lin, Ying-Li</au><au>Hung, Min-Ling</au><au>Lin, I-Ching</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A positive correlation between blood glucose level and bone mineral density in Taiwan</atitle><jtitle>Archives of osteoporosis</jtitle><stitle>Arch Osteoporos</stitle><addtitle>Arch Osteoporos</addtitle><date>2018-07-16</date><risdate>2018</risdate><volume>13</volume><issue>1</issue><spage>78</spage><epage>78</epage><pages>78-78</pages><artnum>78</artnum><issn>1862-3522</issn><eissn>1862-3514</eissn><abstract>Summary
This study was undertaken to assess the effect of blood glucose on BMD and interactions with age, sex, and BMI in a Taiwanese population. Both obese and non-obese people with type 2 diabetes (T2DM) had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood sugar and HbA1c.
Purpose
This study was undertaken to assess the effect of blood glucose on BMD and possible interactions with age, sex, and BMI in a Taiwanese population.
Patients and methods
This study was a retrospective cross-sectional study using data from the Health Examination Database of Changhua Christian Hospital. Data on BMD of the lumbar spine and femoral neck were obtained by dual X-ray absorptiometry (DXA), and other relevant clinical and laboratory data were recorded.
Results
The type 2 diabetes (T2DM) group had a higher BMD than the controls. When comparing the prevalence of osteoporosis between subjects by glucose and HbA1c level, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c. In addition, the BMD of the lumbar spine and femoral neck was higher in the T2DM group than in the controls. Osteoporosis was negatively associated with DM, BMI, and drinking, but positively associated with age, female gender, previous fracture history, and other diseases of the musculoskeletal system and connective tissue. The association between diabetes and osteoporosis remained statistically significant after adjusting for the above factors. T2DM was associated with lower odds of osteoporosis in both obese (OR = 0.77) and non-obese (OR = 0.63) (
p
for interaction = 0.555).
Conclusions
Both obese and non-obese people with T2DM had higher BMD, at lumbar spine and femoral neck, compared with healthy subjects. In addition, the prevalence of osteoporosis significantly decreased with blood glucose and HbA1c.</abstract><cop>London</cop><pub>Springer London</pub><pmid>30009330</pmid><doi>10.1007/s11657-018-0494-9</doi><tpages>1</tpages></addata></record> |
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| subjects | Endocrinology Medicine Medicine & Public Health Original Article Orthopedics |
| title | A positive correlation between blood glucose level and bone mineral density in Taiwan |
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