Diabetes mellitus and drug-induced parkinsonism: A case–control study
Abstract To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case–control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen...
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| Veröffentlicht in: | Journal of the neurological sciences 2009-09, Vol.284 (1), p.140-143 |
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| container_title | Journal of the neurological sciences |
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| creator | Ma, Hyeo-Il Kim, Jin-Hyuck Chu, Min-Kyung Oh, Mi-Sun Yu, Kyung-Ho Kim, Jooyong Hahm, Woong Kim, Yun Joong Lee, Byung-Chul |
| description | Abstract To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case–control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen over the same period at the same hospital. The frequency of diabetes, age-at onset and sex were compared between DIP and IPD or acute stroke. Multivariate analysis showed that patients with diabetes are more frequent in DIP compared with IPD ( p < 0.001, adjusted OR 5.48; 95% CI, 2.52–11.94). The frequency of diabetes in DIP was comparable to that in acute stroke patients ( p = 0.16, adjusted OR 0.62; 95% CI, 0.32–1.21). These data suggest that diabetes may be a risk factor for DIP. Drugs with dopamine receptor blocking potency should be avoided in elderly with diabetes. |
| doi_str_mv | 10.1016/j.jns.2009.05.006 |
| format | Article |
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We performed a hospital-based retrospective case–control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen over the same period at the same hospital. The frequency of diabetes, age-at onset and sex were compared between DIP and IPD or acute stroke. Multivariate analysis showed that patients with diabetes are more frequent in DIP compared with IPD ( p < 0.001, adjusted OR 5.48; 95% CI, 2.52–11.94). The frequency of diabetes in DIP was comparable to that in acute stroke patients ( p = 0.16, adjusted OR 0.62; 95% CI, 0.32–1.21). These data suggest that diabetes may be a risk factor for DIP. Drugs with dopamine receptor blocking potency should be avoided in elderly with diabetes.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2009.05.006</identifier><identifier>PMID: 19467671</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Age of Onset ; Aged ; Biological and medical sciences ; Case–control study ; Contraindications ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetic Neuropathies - complications ; Diabetic Neuropathies - drug therapy ; Disease Susceptibility ; Dopamine Antagonists - adverse effects ; Dopamine D2 Receptor Antagonists ; Drug toxicity and drugs side effects treatment ; Drug-induced parkinsonism ; Female ; Gastroparesis - drug therapy ; Gastroparesis - etiology ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinsonian Disorders - chemically induced ; Parkinsonian Disorders - epidemiology ; Pharmacology. Drug treatments ; Retrospective Studies ; Risk factor ; Risk Factors ; Sex Distribution ; Single-Blind Method ; Stroke - epidemiology ; Sulpiride - adverse effects ; Sulpiride - analogs & derivatives ; Toxicity: nervous system and muscle</subject><ispartof>Journal of the neurological sciences, 2009-09, Vol.284 (1), p.140-143</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-b8b9c45ae7798ff088625f3dd743969faa1de51139da6755f4784813996552403</citedby><cites>FETCH-LOGICAL-c468t-b8b9c45ae7798ff088625f3dd743969faa1de51139da6755f4784813996552403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X09005917$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21845782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19467671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Hyeo-Il</creatorcontrib><creatorcontrib>Kim, Jin-Hyuck</creatorcontrib><creatorcontrib>Chu, Min-Kyung</creatorcontrib><creatorcontrib>Oh, Mi-Sun</creatorcontrib><creatorcontrib>Yu, Kyung-Ho</creatorcontrib><creatorcontrib>Kim, Jooyong</creatorcontrib><creatorcontrib>Hahm, Woong</creatorcontrib><creatorcontrib>Kim, Yun Joong</creatorcontrib><creatorcontrib>Lee, Byung-Chul</creatorcontrib><title>Diabetes mellitus and drug-induced parkinsonism: A case–control study</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Abstract To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case–control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen over the same period at the same hospital. The frequency of diabetes, age-at onset and sex were compared between DIP and IPD or acute stroke. Multivariate analysis showed that patients with diabetes are more frequent in DIP compared with IPD ( p < 0.001, adjusted OR 5.48; 95% CI, 2.52–11.94). The frequency of diabetes in DIP was comparable to that in acute stroke patients ( p = 0.16, adjusted OR 0.62; 95% CI, 0.32–1.21). These data suggest that diabetes may be a risk factor for DIP. Drugs with dopamine receptor blocking potency should be avoided in elderly with diabetes.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case–control study</subject><subject>Contraindications</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetic Neuropathies - complications</subject><subject>Diabetic Neuropathies - drug therapy</subject><subject>Disease Susceptibility</subject><subject>Dopamine Antagonists - adverse effects</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Drug-induced parkinsonism</subject><subject>Female</subject><subject>Gastroparesis - drug therapy</subject><subject>Gastroparesis - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinsonian Disorders - chemically induced</subject><subject>Parkinsonian Disorders - epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Retrospective Studies</subject><subject>Risk factor</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Single-Blind Method</subject><subject>Stroke - epidemiology</subject><subject>Sulpiride - adverse effects</subject><subject>Sulpiride - analogs & derivatives</subject><subject>Toxicity: nervous system and muscle</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQh4Mo7uzqA3iRvuit20q6809BWHZ1FRY8qOAtZJK0pLc7Paa6hbn5Dr6hT2KGGRQ8eCoKvl9V8RUhTyg0FKh4MTRDwoYB6AZ4AyDukQ1VUtVcqfY-2QAwVnMKX87IOeIAhVBKPyRnVHdCCkk35OY62m1YAlZTGMe4rFjZ5Cuf1691TH51wVc7m-9iwjlFnF5Wl5WzGH79-OnmtOR5rHBZ_f4RedDbEcPjU70gn9---XT1rr79cPP-6vK2dp1QS71VW-06boOUWvU9KCUY71vvZddqoXtrqQ-c0lZ7KyTnfSdVp0qrBeesg_aCPD_O3eX52xpwMVNEV063KcwrGgYSOOe0gPQIujwj5tCbXY6TzXtDwRzsmcEUe-ZgzwA3xU3JPD0NX7dT8H8TJ10FeHYCLDo79tkmF_EPx6jquFSscK-OXCgqvseQDboYUpEZc3CL8XP87xmv_0m7MaZYFt6FfcBhXnMqjg01yAyYj4c3H74MGoBrKtvfLKWhtw</recordid><startdate>20090915</startdate><enddate>20090915</enddate><creator>Ma, Hyeo-Il</creator><creator>Kim, Jin-Hyuck</creator><creator>Chu, Min-Kyung</creator><creator>Oh, Mi-Sun</creator><creator>Yu, Kyung-Ho</creator><creator>Kim, Jooyong</creator><creator>Hahm, Woong</creator><creator>Kim, Yun Joong</creator><creator>Lee, Byung-Chul</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20090915</creationdate><title>Diabetes mellitus and drug-induced parkinsonism: A case–control study</title><author>Ma, Hyeo-Il ; Kim, Jin-Hyuck ; Chu, Min-Kyung ; Oh, Mi-Sun ; Yu, Kyung-Ho ; Kim, Jooyong ; Hahm, Woong ; Kim, Yun Joong ; Lee, Byung-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-b8b9c45ae7798ff088625f3dd743969faa1de51139da6755f4784813996552403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age of Onset</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case–control study</topic><topic>Contraindications</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetic Neuropathies - complications</topic><topic>Diabetic Neuropathies - drug therapy</topic><topic>Disease Susceptibility</topic><topic>Dopamine Antagonists - adverse effects</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Drug-induced parkinsonism</topic><topic>Female</topic><topic>Gastroparesis - drug therapy</topic><topic>Gastroparesis - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinsonian Disorders - chemically induced</topic><topic>Parkinsonian Disorders - epidemiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Risk factor</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Single-Blind Method</topic><topic>Stroke - epidemiology</topic><topic>Sulpiride - adverse effects</topic><topic>Sulpiride - analogs & derivatives</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Hyeo-Il</creatorcontrib><creatorcontrib>Kim, Jin-Hyuck</creatorcontrib><creatorcontrib>Chu, Min-Kyung</creatorcontrib><creatorcontrib>Oh, Mi-Sun</creatorcontrib><creatorcontrib>Yu, Kyung-Ho</creatorcontrib><creatorcontrib>Kim, Jooyong</creatorcontrib><creatorcontrib>Hahm, Woong</creatorcontrib><creatorcontrib>Kim, Yun Joong</creatorcontrib><creatorcontrib>Lee, Byung-Chul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Hyeo-Il</au><au>Kim, Jin-Hyuck</au><au>Chu, Min-Kyung</au><au>Oh, Mi-Sun</au><au>Yu, Kyung-Ho</au><au>Kim, Jooyong</au><au>Hahm, Woong</au><au>Kim, Yun Joong</au><au>Lee, Byung-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes mellitus and drug-induced parkinsonism: A case–control study</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2009-09-15</date><risdate>2009</risdate><volume>284</volume><issue>1</issue><spage>140</spage><epage>143</epage><pages>140-143</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Abstract To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case–control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were seen over the same period at the same hospital. The frequency of diabetes, age-at onset and sex were compared between DIP and IPD or acute stroke. Multivariate analysis showed that patients with diabetes are more frequent in DIP compared with IPD ( p < 0.001, adjusted OR 5.48; 95% CI, 2.52–11.94). The frequency of diabetes in DIP was comparable to that in acute stroke patients ( p = 0.16, adjusted OR 0.62; 95% CI, 0.32–1.21). These data suggest that diabetes may be a risk factor for DIP. Drugs with dopamine receptor blocking potency should be avoided in elderly with diabetes.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19467671</pmid><doi>10.1016/j.jns.2009.05.006</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age of Onset Aged Biological and medical sciences Case–control study Contraindications Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetic Neuropathies - complications Diabetic Neuropathies - drug therapy Disease Susceptibility Dopamine Antagonists - adverse effects Dopamine D2 Receptor Antagonists Drug toxicity and drugs side effects treatment Drug-induced parkinsonism Female Gastroparesis - drug therapy Gastroparesis - etiology Humans Male Medical sciences Middle Aged Neurology Parkinsonian Disorders - chemically induced Parkinsonian Disorders - epidemiology Pharmacology. Drug treatments Retrospective Studies Risk factor Risk Factors Sex Distribution Single-Blind Method Stroke - epidemiology Sulpiride - adverse effects Sulpiride - analogs & derivatives Toxicity: nervous system and muscle |
| title | Diabetes mellitus and drug-induced parkinsonism: A case–control study |
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