Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway

β-Carotene-15, 15′-oxygenase (BCO1) and β-carotene-9′, 10′-oxygenase (BCO2) are essential enzymes in carotenoid metabolism. While BCO1/BCO2 polymorphisms have been associated with alterations to human and animal carotenoid levels, experimental studies have suggested that BCO1 and BCO2 may have speci...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2018-09, Vol.654, p.1-9
Hauptverfasser:	Lim, Ji Ye, Liu, Chun, Hu, Kang-Quan, Smith, Donald E., Wang, Xiang-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Carotene 15,15'-Monooxygenase - genetics beta-Carotene 15,15'-Monooxygenase - metabolism Biomarkers - metabolism Carotenoid cleavage enzymes Carotenoids - metabolism Cholesterol - metabolism Dioxygenases - genetics Dioxygenases - metabolism Farnesoid X receptor Fatty liver disease Hydrolysis Lipid Metabolism Liver - metabolism Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs - metabolism Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Oxidative Stress Polymorphism, Single Nucleotide Receptors, Cytoplasmic and Nuclear - metabolism Sirtuin 1 Sirtuin 1 - metabolism Triglycerides - metabolism
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