Proteomic profiles by multiplex microsphere suspension array
Advances in high-throughput proteomic approaches have provided substantial momentum to novel disease-biomarker discovery research and have augmented the quality of clinical studies. Applications based on multiplexed microsphere suspension array technology are making strong in-roads into the clinical...
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| Veröffentlicht in: | Journal of immunological methods 2018-10, Vol.461, p.1-14 |
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| container_title | Journal of immunological methods |
| container_volume | 461 |
| creator | Krishnan, Viswanathan V. Selvan, Senthamil R. Parameswaran, Nishanth Venkateswaran, Neeraja Luciw, Paul A. Venkateswaran, Kodumudi S. |
| description | Advances in high-throughput proteomic approaches have provided substantial momentum to novel disease-biomarker discovery research and have augmented the quality of clinical studies. Applications based on multiplexed microsphere suspension array technology are making strong in-roads into the clinical diagnostic/prognostic practice. Conventional proteomic approaches are designed to discover a broad set of proteins that are associated with a specific medical condition. In comparison, multiplex microsphere immunoassays use quantitative measurements of selected set(s) of specific/particular molecular markers such as cytokines, chemokines, pathway signaling or disease-specific markers for detection, metabolic disorders, cancer, and infectious agents causing human, plant and animal diseases. This article provides a foundation to the multiplexed microsphere suspension array technology, with an emphasis on the improvements in the technology, data analysis approaches, and applications to translational and clinical research with implications for personalized and precision medicine. |
| doi_str_mv | 10.1016/j.jim.2018.07.002 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Journal of immunological methods, 2018-10, Vol.461, p.1-14 |
| issn | 0022-1759 1872-7905 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biomarkers Biomarkers - metabolism Flow Cytometry - instrumentation Flow Cytometry - methods Humans Immunoassay Immunoassay - instrumentation Immunoassay - methods Microbead Array Microspheres Multiplex Assay Proteomics Proteomics - instrumentation Proteomics - methods |
| title | Proteomic profiles by multiplex microsphere suspension array |
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