Effects of single and combined metformin and l-citrulline supplementation on l-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications

The l -arginine/nitric oxide synthase (NOS) pathway is considered to be altered in muscular dystrophy such as Becker muscular dystrophy (BMD). We investigated two pharmacological options aimed to increase nitric oxide (NO) synthesis in 20 male BMD patients (age range 21–44 years): (1) supplementatio...

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Veröffentlicht in:	Amino acids 2018-10, Vol.50 (10), p.1391-1406
Hauptverfasser:	Hanff, Erik, Hafner, Patricia, Bollenbach, Alexander, Bonati, Ulrike, Kayacelebi, Arslan Arinc, Fischer, Dirk, Tsikas, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analytical Chemistry Antidiabetics Arginine Becker's muscular dystrophy Biochemical Engineering Biochemistry Biomarkers Biomedical and Life Sciences Bone mineral density Citrulline Creatinine Diabetes mellitus Excretion Glycine Glycine amidinotransferase Guanidinoacetate N-methyltransferase Life Sciences Malondialdehyde Metabolites Metformin Methyltransferase Muscles Muscular dystrophy Neurobiology Nitric oxide Nitric-oxide synthase Original Article Oxidative stress Patients Pharmacology Proteomics Skeletal muscle Substrates Supplements Urine
Online-Zugang:	Volltext
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