Brain organoids as models to study human neocortex development and evolution

Brain organoids as models to study human neocortex development and evolution

Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in cell biology 2018-12, Vol.55, p.8-16
Hauptverfasser: Heide, Michael, Huttner, Wieland B, Mora-Bermúdez, Felipe
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 16
container_issue
container_start_page 8
container_title Current opinion in cell biology
container_volume 55
creator Heide, Michael
Huttner, Wieland B
Mora-Bermúdez, Felipe
description Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.
doi_str_mv 10.1016/j.ceb.2018.06.006
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2070250283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0955067417301655</els_id><sourcerecordid>2070250283</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-51d1ca5273abc841fc6fa596d632021bf73cf8b6e5394d3039e1d97ac704d74e3</originalsourceid><addsrcrecordid>eNp9kD1PwzAURS0EoqXwA1iQR5aE5zh2EjEB4kuqxAKz5dgv4CqJi51U8O8JtDAyvTuce_V0CDllkDJg8mKVGqzTDFiZgkwB5B6Zs7KoEsgZ7JM5VEIkIIt8Ro5iXMFEQFYdkhn_iSKfk-V10K6nPrzq3jsbqY608xbbSAdP4zDaT_o2drqnPXrjw4Af1OIGW7_usB-o7i3FjW_Hwfn-mBw0uo14srsL8nJ3-3zzkCyf7h9vrpaJ4YIPiWCWGS2yguvalDlrjGy0qKSVPIOM1U3BTVPWEgWvcsuBV8hsVWhTQG6LHPmCnG9318G_jxgH1blosG319OQYVQYFZAKykk8o26Im-BgDNmodXKfDp2KgviWqlZokqm-JCqSavEyds938WHdo_xq_1ibgcgtMmnDjMKhoHPYGrQtoBmW9-2f-C68mgho</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070250283</pqid></control><display><type>article</type><title>Brain organoids as models to study human neocortex development and evolution</title><source>Elsevier ScienceDirect Journals</source><creator>Heide, Michael ; Huttner, Wieland B ; Mora-Bermúdez, Felipe</creator><creatorcontrib>Heide, Michael ; Huttner, Wieland B ; Mora-Bermúdez, Felipe</creatorcontrib><description>Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/j.ceb.2018.06.006</identifier><identifier>PMID: 30006054</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>Current opinion in cell biology, 2018-12, Vol.55, p.8-16</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-51d1ca5273abc841fc6fa596d632021bf73cf8b6e5394d3039e1d97ac704d74e3</citedby><cites>FETCH-LOGICAL-c353t-51d1ca5273abc841fc6fa596d632021bf73cf8b6e5394d3039e1d97ac704d74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0955067417301655$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30006054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heide, Michael</creatorcontrib><creatorcontrib>Huttner, Wieland B</creatorcontrib><creatorcontrib>Mora-Bermúdez, Felipe</creatorcontrib><title>Brain organoids as models to study human neocortex development and evolution</title><title>Current opinion in cell biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.</description><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAURS0EoqXwA1iQR5aE5zh2EjEB4kuqxAKz5dgv4CqJi51U8O8JtDAyvTuce_V0CDllkDJg8mKVGqzTDFiZgkwB5B6Zs7KoEsgZ7JM5VEIkIIt8Ro5iXMFEQFYdkhn_iSKfk-V10K6nPrzq3jsbqY608xbbSAdP4zDaT_o2drqnPXrjw4Af1OIGW7_usB-o7i3FjW_Hwfn-mBw0uo14srsL8nJ3-3zzkCyf7h9vrpaJ4YIPiWCWGS2yguvalDlrjGy0qKSVPIOM1U3BTVPWEgWvcsuBV8hsVWhTQG6LHPmCnG9318G_jxgH1blosG319OQYVQYFZAKykk8o26Im-BgDNmodXKfDp2KgviWqlZokqm-JCqSavEyds938WHdo_xq_1ibgcgtMmnDjMKhoHPYGrQtoBmW9-2f-C68mgho</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Heide, Michael</creator><creator>Huttner, Wieland B</creator><creator>Mora-Bermúdez, Felipe</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Brain organoids as models to study human neocortex development and evolution</title><author>Heide, Michael ; Huttner, Wieland B ; Mora-Bermúdez, Felipe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-51d1ca5273abc841fc6fa596d632021bf73cf8b6e5394d3039e1d97ac704d74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heide, Michael</creatorcontrib><creatorcontrib>Huttner, Wieland B</creatorcontrib><creatorcontrib>Mora-Bermúdez, Felipe</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heide, Michael</au><au>Huttner, Wieland B</au><au>Mora-Bermúdez, Felipe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain organoids as models to study human neocortex development and evolution</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>55</volume><spage>8</spage><epage>16</epage><pages>8-16</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30006054</pmid><doi>10.1016/j.ceb.2018.06.006</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0955-0674
ispartof Current opinion in cell biology, 2018-12, Vol.55, p.8-16
issn 0955-0674
1879-0410
language eng
recordid cdi_proquest_miscellaneous_2070250283
source Elsevier ScienceDirect Journals
title Brain organoids as models to study human neocortex development and evolution
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T17%3A54%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Brain%20organoids%20as%20models%20to%20study%20human%20neocortex%20development%20and%20evolution&rft.jtitle=Current%20opinion%20in%20cell%20biology&rft.au=Heide,%20Michael&rft.date=2018-12&rft.volume=55&rft.spage=8&rft.epage=16&rft.pages=8-16&rft.issn=0955-0674&rft.eissn=1879-0410&rft_id=info:doi/10.1016/j.ceb.2018.06.006&rft_dat=%3Cproquest_cross%3E2070250283%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2070250283&rft_id=info:pmid/30006054&rft_els_id=S0955067417301655&rfr_iscdi=true