Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients
To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female health...
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| Veröffentlicht in: | Clinical rheumatology 2018-10, Vol.37 (10), p.2869-2873 |
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| creator | Tomioka, Renato B. Ferreira, Gabriela R. V. Aikawa, Nadia E. Maciel, Gustavo A. R. Serafini, Paulo C. Sallum, Adriana M. Campos, Lucia M. A. Goldestein-Schainberg, Claudia Bonfá, Eloisa Silva, Clovis A. |
| description | To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine. Comparison between JIA patients with (
n
= 8) vs. without NSAIDs (
n
= 15) and healthy controls (
n
= 11) revealed that LUF syndrome was significantly higher in the former group (2 (25%) vs. 0% vs. 0%,
p
= 0.049). These two patients with LUF syndrome had normal menstrual cycles without reduced ovarian reserve, and they were under naproxen 500 mg bid during the menstrual cycle. Disease duration was comparable in JIA with and without NSAIDs [19.8 (4.4–25) vs. 13 (3.1–33) years,
p
= 0.232]. Further comparison between JIA patients with and without NSAIDs and healthy controls showed similar mean anti-Müllerian hormone levels (
p
= 0.909), estradiol (
p
= 0.436), FSH (
p
= 0.662), LH (
p
= 0.686), and mean antral follicle count (
p
= 0.240) and ovarian volume (
p
= 0.363). No differences were evidenced in three groups regarding Caucasian race, body mass index, duration, and length of menstrual cycles (
p
> 0.05). This is the first study to identify that JIA patients have a high frequency of LUF without impaired ovarian reserve. Future prospective studies are necessary to determine if chronic/continuous use of NSAIDs in JIA will have an impact in these patients’ fertility. |
| doi_str_mv | 10.1007/s10067-018-4208-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2070248094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070248094</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-ad86095b4bd465a51f84ed121c65151184696cedd09e9054e40f7128fa505ce53</originalsourceid><addsrcrecordid>eNp1kc-KFDEQxoMo7uzqA3iRgBcv0Up30p0cZVl1YdGLnptMp3o2QzoZ80d2fAVf2iyzKgheqj5Sv_oq8BHygsMbDjC-za0OIwOumOhAsbtHZMNFL5jWQj8mGxhHYD3X6oyc57wHgE5p_pSc9U32QvAN-fkpBpYLpuis8dSE4pgLizfrakpMR2pT3VEXbJ0xU18LuuB-oKU1pHooNTW5RO_d7JHmY7Aprth4eow17OiCq2mDff2OwTXhrIsHU27dTE0qt8kVl2l7cBhKfkaeLMZnfP7QL8jX91dfLj-ym88fri_f3bC516owY9UAWm7F1opBGskXJdDyjs-D5JJzJQY9zGgtaNQgBQpYRt6pxUiQM8r-grw--R5S_FYxl2l1eUbvTcBY89TBCJ1QoEVDX_2D7mNNof2uUYMapFCKN4qfqDnFnBMu0yG51aTjxGG6T2o6JTW1pKb7pKa7tvPywbluV7R_Nn5H04DuBOQ2CjtMf0__3_UXcXah7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068654881</pqid></control><display><type>article</type><title>Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Tomioka, Renato B. ; Ferreira, Gabriela R. V. ; Aikawa, Nadia E. ; Maciel, Gustavo A. R. ; Serafini, Paulo C. ; Sallum, Adriana M. ; Campos, Lucia M. A. ; Goldestein-Schainberg, Claudia ; Bonfá, Eloisa ; Silva, Clovis A.</creator><creatorcontrib>Tomioka, Renato B. ; Ferreira, Gabriela R. V. ; Aikawa, Nadia E. ; Maciel, Gustavo A. R. ; Serafini, Paulo C. ; Sallum, Adriana M. ; Campos, Lucia M. A. ; Goldestein-Schainberg, Claudia ; Bonfá, Eloisa ; Silva, Clovis A.</creatorcontrib><description>To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine. Comparison between JIA patients with (
n
= 8) vs. without NSAIDs (
n
= 15) and healthy controls (
n
= 11) revealed that LUF syndrome was significantly higher in the former group (2 (25%) vs. 0% vs. 0%,
p
= 0.049). These two patients with LUF syndrome had normal menstrual cycles without reduced ovarian reserve, and they were under naproxen 500 mg bid during the menstrual cycle. Disease duration was comparable in JIA with and without NSAIDs [19.8 (4.4–25) vs. 13 (3.1–33) years,
p
= 0.232]. Further comparison between JIA patients with and without NSAIDs and healthy controls showed similar mean anti-Müllerian hormone levels (
p
= 0.909), estradiol (
p
= 0.436), FSH (
p
= 0.662), LH (
p
= 0.686), and mean antral follicle count (
p
= 0.240) and ovarian volume (
p
= 0.363). No differences were evidenced in three groups regarding Caucasian race, body mass index, duration, and length of menstrual cycles (
p
> 0.05). This is the first study to identify that JIA patients have a high frequency of LUF without impaired ovarian reserve. Future prospective studies are necessary to determine if chronic/continuous use of NSAIDs in JIA will have an impact in these patients’ fertility.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-018-4208-x</identifier><identifier>PMID: 30003441</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>17β-Estradiol ; Adolescent ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis ; Arthritis, Juvenile - drug therapy ; Body mass index ; Brief Report ; Female ; Fertility ; Follicle-stimulating hormone ; Humans ; Inflammation ; Luteinizing hormone ; Medicine ; Medicine & Public Health ; Menstrual cycle ; Menstruation ; Naproxen ; Nonsteroidal anti-inflammatory drugs ; Ovarian Diseases - chemically induced ; Ovarian Diseases - diagnostic imaging ; Ovarian Follicle - diagnostic imaging ; Ovulation ; Progesterone ; Rheumatology ; Ultrasonic imaging ; Ultrasonography ; Ultrasound ; Urine ; Young Adult</subject><ispartof>Clinical rheumatology, 2018-10, Vol.37 (10), p.2869-2873</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2018</rights><rights>Clinical Rheumatology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-ad86095b4bd465a51f84ed121c65151184696cedd09e9054e40f7128fa505ce53</citedby><cites>FETCH-LOGICAL-c398t-ad86095b4bd465a51f84ed121c65151184696cedd09e9054e40f7128fa505ce53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-018-4208-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-018-4208-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30003441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomioka, Renato B.</creatorcontrib><creatorcontrib>Ferreira, Gabriela R. V.</creatorcontrib><creatorcontrib>Aikawa, Nadia E.</creatorcontrib><creatorcontrib>Maciel, Gustavo A. R.</creatorcontrib><creatorcontrib>Serafini, Paulo C.</creatorcontrib><creatorcontrib>Sallum, Adriana M.</creatorcontrib><creatorcontrib>Campos, Lucia M. A.</creatorcontrib><creatorcontrib>Goldestein-Schainberg, Claudia</creatorcontrib><creatorcontrib>Bonfá, Eloisa</creatorcontrib><creatorcontrib>Silva, Clovis A.</creatorcontrib><title>Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine. Comparison between JIA patients with (
n
= 8) vs. without NSAIDs (
n
= 15) and healthy controls (
n
= 11) revealed that LUF syndrome was significantly higher in the former group (2 (25%) vs. 0% vs. 0%,
p
= 0.049). These two patients with LUF syndrome had normal menstrual cycles without reduced ovarian reserve, and they were under naproxen 500 mg bid during the menstrual cycle. Disease duration was comparable in JIA with and without NSAIDs [19.8 (4.4–25) vs. 13 (3.1–33) years,
p
= 0.232]. Further comparison between JIA patients with and without NSAIDs and healthy controls showed similar mean anti-Müllerian hormone levels (
p
= 0.909), estradiol (
p
= 0.436), FSH (
p
= 0.662), LH (
p
= 0.686), and mean antral follicle count (
p
= 0.240) and ovarian volume (
p
= 0.363). No differences were evidenced in three groups regarding Caucasian race, body mass index, duration, and length of menstrual cycles (
p
> 0.05). This is the first study to identify that JIA patients have a high frequency of LUF without impaired ovarian reserve. Future prospective studies are necessary to determine if chronic/continuous use of NSAIDs in JIA will have an impact in these patients’ fertility.</description><subject>17β-Estradiol</subject><subject>Adolescent</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Body mass index</subject><subject>Brief Report</subject><subject>Female</subject><subject>Fertility</subject><subject>Follicle-stimulating hormone</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Luteinizing hormone</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menstrual cycle</subject><subject>Menstruation</subject><subject>Naproxen</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Ovarian Diseases - chemically induced</subject><subject>Ovarian Diseases - diagnostic imaging</subject><subject>Ovarian Follicle - diagnostic imaging</subject><subject>Ovulation</subject><subject>Progesterone</subject><subject>Rheumatology</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><subject>Urine</subject><subject>Young Adult</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc-KFDEQxoMo7uzqA3iRgBcv0Up30p0cZVl1YdGLnptMp3o2QzoZ80d2fAVf2iyzKgheqj5Sv_oq8BHygsMbDjC-za0OIwOumOhAsbtHZMNFL5jWQj8mGxhHYD3X6oyc57wHgE5p_pSc9U32QvAN-fkpBpYLpuis8dSE4pgLizfrakpMR2pT3VEXbJ0xU18LuuB-oKU1pHooNTW5RO_d7JHmY7Aprth4eow17OiCq2mDff2OwTXhrIsHU27dTE0qt8kVl2l7cBhKfkaeLMZnfP7QL8jX91dfLj-ym88fri_f3bC516owY9UAWm7F1opBGskXJdDyjs-D5JJzJQY9zGgtaNQgBQpYRt6pxUiQM8r-grw--R5S_FYxl2l1eUbvTcBY89TBCJ1QoEVDX_2D7mNNof2uUYMapFCKN4qfqDnFnBMu0yG51aTjxGG6T2o6JTW1pKb7pKa7tvPywbluV7R_Nn5H04DuBOQ2CjtMf0__3_UXcXah7w</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Tomioka, Renato B.</creator><creator>Ferreira, Gabriela R. V.</creator><creator>Aikawa, Nadia E.</creator><creator>Maciel, Gustavo A. R.</creator><creator>Serafini, Paulo C.</creator><creator>Sallum, Adriana M.</creator><creator>Campos, Lucia M. A.</creator><creator>Goldestein-Schainberg, Claudia</creator><creator>Bonfá, Eloisa</creator><creator>Silva, Clovis A.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients</title><author>Tomioka, Renato B. ; Ferreira, Gabriela R. V. ; Aikawa, Nadia E. ; Maciel, Gustavo A. R. ; Serafini, Paulo C. ; Sallum, Adriana M. ; Campos, Lucia M. A. ; Goldestein-Schainberg, Claudia ; Bonfá, Eloisa ; Silva, Clovis A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-ad86095b4bd465a51f84ed121c65151184696cedd09e9054e40f7128fa505ce53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>17β-Estradiol</topic><topic>Adolescent</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Body mass index</topic><topic>Brief Report</topic><topic>Female</topic><topic>Fertility</topic><topic>Follicle-stimulating hormone</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Luteinizing hormone</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menstrual cycle</topic><topic>Menstruation</topic><topic>Naproxen</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Ovarian Diseases - chemically induced</topic><topic>Ovarian Diseases - diagnostic imaging</topic><topic>Ovarian Follicle - diagnostic imaging</topic><topic>Ovulation</topic><topic>Progesterone</topic><topic>Rheumatology</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><topic>Urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomioka, Renato B.</creatorcontrib><creatorcontrib>Ferreira, Gabriela R. V.</creatorcontrib><creatorcontrib>Aikawa, Nadia E.</creatorcontrib><creatorcontrib>Maciel, Gustavo A. R.</creatorcontrib><creatorcontrib>Serafini, Paulo C.</creatorcontrib><creatorcontrib>Sallum, Adriana M.</creatorcontrib><creatorcontrib>Campos, Lucia M. A.</creatorcontrib><creatorcontrib>Goldestein-Schainberg, Claudia</creatorcontrib><creatorcontrib>Bonfá, Eloisa</creatorcontrib><creatorcontrib>Silva, Clovis A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomioka, Renato B.</au><au>Ferreira, Gabriela R. V.</au><au>Aikawa, Nadia E.</au><au>Maciel, Gustavo A. R.</au><au>Serafini, Paulo C.</au><au>Sallum, Adriana M.</au><au>Campos, Lucia M. A.</au><au>Goldestein-Schainberg, Claudia</au><au>Bonfá, Eloisa</au><au>Silva, Clovis A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>37</volume><issue>10</issue><spage>2869</spage><epage>2873</epage><pages>2869-2873</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>To assess prospectively luteinized unruptured follicle (LUF) syndrome in juvenile idiopathic arthritis (JIA) patients with and without non-steroidal anti-inflammatory drugs (NSAIDs) and healthy controls. Twenty-three adolescent and young adult female JIA patients (ILAR criteria) and 11 female healthy subjects were studied by pelvic ultrasound monitoring for follicular development and ovulation in one menstrual cycle. LUF syndrome was prospectively investigated by pelvic ultrasound with a dominant ovarian follicle without signs of follicular rupture, with elevation of serum progesterone in the luteal phase of the menstrual cycle and luteinizing hormone (LH) detected in the urine. Comparison between JIA patients with (
n
= 8) vs. without NSAIDs (
n
= 15) and healthy controls (
n
= 11) revealed that LUF syndrome was significantly higher in the former group (2 (25%) vs. 0% vs. 0%,
p
= 0.049). These two patients with LUF syndrome had normal menstrual cycles without reduced ovarian reserve, and they were under naproxen 500 mg bid during the menstrual cycle. Disease duration was comparable in JIA with and without NSAIDs [19.8 (4.4–25) vs. 13 (3.1–33) years,
p
= 0.232]. Further comparison between JIA patients with and without NSAIDs and healthy controls showed similar mean anti-Müllerian hormone levels (
p
= 0.909), estradiol (
p
= 0.436), FSH (
p
= 0.662), LH (
p
= 0.686), and mean antral follicle count (
p
= 0.240) and ovarian volume (
p
= 0.363). No differences were evidenced in three groups regarding Caucasian race, body mass index, duration, and length of menstrual cycles (
p
> 0.05). This is the first study to identify that JIA patients have a high frequency of LUF without impaired ovarian reserve. Future prospective studies are necessary to determine if chronic/continuous use of NSAIDs in JIA will have an impact in these patients’ fertility.</abstract><cop>London</cop><pub>Springer London</pub><pmid>30003441</pmid><doi>10.1007/s10067-018-4208-x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical rheumatology, 2018-10, Vol.37 (10), p.2869-2873 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | 17β-Estradiol Adolescent Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis Arthritis, Juvenile - drug therapy Body mass index Brief Report Female Fertility Follicle-stimulating hormone Humans Inflammation Luteinizing hormone Medicine Medicine & Public Health Menstrual cycle Menstruation Naproxen Nonsteroidal anti-inflammatory drugs Ovarian Diseases - chemically induced Ovarian Diseases - diagnostic imaging Ovarian Follicle - diagnostic imaging Ovulation Progesterone Rheumatology Ultrasonic imaging Ultrasonography Ultrasound Urine Young Adult |
| title | Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients |
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