Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up
This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups. Of 173 patients over 6...
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| Veröffentlicht in: | Breast (Edinburgh) 2018-10, Vol.41, p.74-81 |
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| creator | Arraras, Juan Ignacio Manterola, Ana Illarramendi, Jose Juan Asin, Gemma de la Cruz, Susana Ibañez, Berta Galbete, Arkaitz Salgado, Esteban Zarandona, Uxue Vera, Ruth Dominguez, Miguel Angel Martinez, Enrique |
| description | This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups.
Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT.
Longitudinal changes in QL were assessed for the whole sample using linear mixed-effect models. Also assessed were differences in QL scores between axillary treatment groups (axillary node dissection ALND, sentinel lymph node biopsy SLNB, and no surgery) at the end of the follow-up (Anova or Kruskal-Wallis) and differences in the evolution of QL from baseline among these groups (linear regression models).
QL scores in the follow-up were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment. Five areas (pain, nausea/vomiting, financial impact, breast symptoms and IDDD) improved significantly ( |
| doi_str_mv | 10.1016/j.breast.2018.06.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2070247508</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S096097761830122X</els_id><sourcerecordid>2070247508</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-5928810712ddfd6c91d1d831cbe9e3a3e8163fdb25492d697e4c9826996503643</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi1ERZeWf4CQj1wSxnbixBckVPElVUJI7dny2hOtV971Yjuplhv_HJcUjpz89bwznoeQ1wxaBky-27fbhCaXlgMbW5AtMHhGNqwXvBEwwnOyASWhUcMgL8nLnPcAoIQcX5BLUbcDH9iG_Po-m-DLmcaJBj8hxSWGufh4pP5IMThM4UzznBa_xJTpgy87GqKtoZ_o6PoFas3RYqKlnkq9_QMl43wsO0zmVKsv9dnQskuIzRlNolMMIT408-maXEwmZHz1tF6R-08f726-NLffPn-9-XDbWCF5aXrFx5HBwLhzk5NWMcfcKJjdokJhBI5Mislted8p7qQasLNq5FIp2YOQnbgib9e6pxR_zJiLPvhsMQRzxDhnzWEA3g09jBXtVtSmmHPCSZ-SP5h01gz0o3y91-vk-lG-Bqmr_Bp789Rh3h7Q_Qv9tV2B9yuAdc7FY9LZeqzqnE9oi3bR_7_Db8PhmXk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070247508</pqid></control><display><type>article</type><title>Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Arraras, Juan Ignacio ; Manterola, Ana ; Illarramendi, Jose Juan ; Asin, Gemma ; de la Cruz, Susana ; Ibañez, Berta ; Galbete, Arkaitz ; Salgado, Esteban ; Zarandona, Uxue ; Vera, Ruth ; Dominguez, Miguel Angel ; Martinez, Enrique</creator><creatorcontrib>Arraras, Juan Ignacio ; Manterola, Ana ; Illarramendi, Jose Juan ; Asin, Gemma ; de la Cruz, Susana ; Ibañez, Berta ; Galbete, Arkaitz ; Salgado, Esteban ; Zarandona, Uxue ; Vera, Ruth ; Dominguez, Miguel Angel ; Martinez, Enrique</creatorcontrib><description>This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups.
Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT.
Longitudinal changes in QL were assessed for the whole sample using linear mixed-effect models. Also assessed were differences in QL scores between axillary treatment groups (axillary node dissection ALND, sentinel lymph node biopsy SLNB, and no surgery) at the end of the follow-up (Anova or Kruskal-Wallis) and differences in the evolution of QL from baseline among these groups (linear regression models).
QL scores in the follow-up were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment. Five areas (pain, nausea/vomiting, financial impact, breast symptoms and IDDD) improved significantly (<6 points) in the follow-up.
The ALND group scored less for the future perspective item (15–20 points) in the follow-up than the other two axillary treatment groups. No differences between the pre-treatment and follow up assessments regarding treatment were found among the axillary treatment groups.
Our results suggest that early-stage breast cancer patients adapted well both to their disease and treatments over the follow-up period and to the administration of RT. There were few QL differences between the axillary treatment groups.
•QL in elderly early-stage breast cancer survivors treated with RT was high.•Limitations in sexuality areas were moderate.•QL 3 years after the end of RT was higher than pre-RT scores.•Patients who received axillary node dissection had less future perspective.•Patients adapted well to their disease and treatment.</description><identifier>ISSN: 0960-9776</identifier><identifier>EISSN: 1532-3080</identifier><identifier>DOI: 10.1016/j.breast.2018.06.010</identifier><identifier>PMID: 30007271</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Axilla - pathology ; Axilla - surgery ; Breast cancer ; Breast Neoplasms - psychology ; Breast Neoplasms - radiotherapy ; Cancer Survivors - psychology ; Cancer Survivors - statistics & numerical data ; Elderly ; EORTC ; Female ; Follow-Up Studies ; Humans ; Lymph Node Excision - statistics & numerical data ; Lymphatic Metastasis ; Mastectomy - statistics & numerical data ; Middle Aged ; Quality of Life ; Radiotherapy ; Spain ; Surveys and Questionnaires ; Survivor</subject><ispartof>Breast (Edinburgh), 2018-10, Vol.41, p.74-81</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-5928810712ddfd6c91d1d831cbe9e3a3e8163fdb25492d697e4c9826996503643</citedby><cites>FETCH-LOGICAL-c362t-5928810712ddfd6c91d1d831cbe9e3a3e8163fdb25492d697e4c9826996503643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.breast.2018.06.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30007271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arraras, Juan Ignacio</creatorcontrib><creatorcontrib>Manterola, Ana</creatorcontrib><creatorcontrib>Illarramendi, Jose Juan</creatorcontrib><creatorcontrib>Asin, Gemma</creatorcontrib><creatorcontrib>de la Cruz, Susana</creatorcontrib><creatorcontrib>Ibañez, Berta</creatorcontrib><creatorcontrib>Galbete, Arkaitz</creatorcontrib><creatorcontrib>Salgado, Esteban</creatorcontrib><creatorcontrib>Zarandona, Uxue</creatorcontrib><creatorcontrib>Vera, Ruth</creatorcontrib><creatorcontrib>Dominguez, Miguel Angel</creatorcontrib><creatorcontrib>Martinez, Enrique</creatorcontrib><title>Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up</title><title>Breast (Edinburgh)</title><addtitle>Breast</addtitle><description>This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups.
Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT.
Longitudinal changes in QL were assessed for the whole sample using linear mixed-effect models. Also assessed were differences in QL scores between axillary treatment groups (axillary node dissection ALND, sentinel lymph node biopsy SLNB, and no surgery) at the end of the follow-up (Anova or Kruskal-Wallis) and differences in the evolution of QL from baseline among these groups (linear regression models).
QL scores in the follow-up were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment. Five areas (pain, nausea/vomiting, financial impact, breast symptoms and IDDD) improved significantly (<6 points) in the follow-up.
The ALND group scored less for the future perspective item (15–20 points) in the follow-up than the other two axillary treatment groups. No differences between the pre-treatment and follow up assessments regarding treatment were found among the axillary treatment groups.
Our results suggest that early-stage breast cancer patients adapted well both to their disease and treatments over the follow-up period and to the administration of RT. There were few QL differences between the axillary treatment groups.
•QL in elderly early-stage breast cancer survivors treated with RT was high.•Limitations in sexuality areas were moderate.•QL 3 years after the end of RT was higher than pre-RT scores.•Patients who received axillary node dissection had less future perspective.•Patients adapted well to their disease and treatment.</description><subject>Aged</subject><subject>Axilla - pathology</subject><subject>Axilla - surgery</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - psychology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cancer Survivors - psychology</subject><subject>Cancer Survivors - statistics & numerical data</subject><subject>Elderly</subject><subject>EORTC</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymph Node Excision - statistics & numerical data</subject><subject>Lymphatic Metastasis</subject><subject>Mastectomy - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Quality of Life</subject><subject>Radiotherapy</subject><subject>Spain</subject><subject>Surveys and Questionnaires</subject><subject>Survivor</subject><issn>0960-9776</issn><issn>1532-3080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERZeWf4CQj1wSxnbixBckVPElVUJI7dny2hOtV971Yjuplhv_HJcUjpz89bwznoeQ1wxaBky-27fbhCaXlgMbW5AtMHhGNqwXvBEwwnOyASWhUcMgL8nLnPcAoIQcX5BLUbcDH9iG_Po-m-DLmcaJBj8hxSWGufh4pP5IMThM4UzznBa_xJTpgy87GqKtoZ_o6PoFas3RYqKlnkq9_QMl43wsO0zmVKsv9dnQskuIzRlNolMMIT408-maXEwmZHz1tF6R-08f726-NLffPn-9-XDbWCF5aXrFx5HBwLhzk5NWMcfcKJjdokJhBI5Mislted8p7qQasLNq5FIp2YOQnbgib9e6pxR_zJiLPvhsMQRzxDhnzWEA3g09jBXtVtSmmHPCSZ-SP5h01gz0o3y91-vk-lG-Bqmr_Bp789Rh3h7Q_Qv9tV2B9yuAdc7FY9LZeqzqnE9oi3bR_7_Db8PhmXk</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Arraras, Juan Ignacio</creator><creator>Manterola, Ana</creator><creator>Illarramendi, Jose Juan</creator><creator>Asin, Gemma</creator><creator>de la Cruz, Susana</creator><creator>Ibañez, Berta</creator><creator>Galbete, Arkaitz</creator><creator>Salgado, Esteban</creator><creator>Zarandona, Uxue</creator><creator>Vera, Ruth</creator><creator>Dominguez, Miguel Angel</creator><creator>Martinez, Enrique</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up</title><author>Arraras, Juan Ignacio ; Manterola, Ana ; Illarramendi, Jose Juan ; Asin, Gemma ; de la Cruz, Susana ; Ibañez, Berta ; Galbete, Arkaitz ; Salgado, Esteban ; Zarandona, Uxue ; Vera, Ruth ; Dominguez, Miguel Angel ; Martinez, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-5928810712ddfd6c91d1d831cbe9e3a3e8163fdb25492d697e4c9826996503643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Axilla - pathology</topic><topic>Axilla - surgery</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - psychology</topic><topic>Breast Neoplasms - radiotherapy</topic><topic>Cancer Survivors - psychology</topic><topic>Cancer Survivors - statistics & numerical data</topic><topic>Elderly</topic><topic>EORTC</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lymph Node Excision - statistics & numerical data</topic><topic>Lymphatic Metastasis</topic><topic>Mastectomy - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Quality of Life</topic><topic>Radiotherapy</topic><topic>Spain</topic><topic>Surveys and Questionnaires</topic><topic>Survivor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arraras, Juan Ignacio</creatorcontrib><creatorcontrib>Manterola, Ana</creatorcontrib><creatorcontrib>Illarramendi, Jose Juan</creatorcontrib><creatorcontrib>Asin, Gemma</creatorcontrib><creatorcontrib>de la Cruz, Susana</creatorcontrib><creatorcontrib>Ibañez, Berta</creatorcontrib><creatorcontrib>Galbete, Arkaitz</creatorcontrib><creatorcontrib>Salgado, Esteban</creatorcontrib><creatorcontrib>Zarandona, Uxue</creatorcontrib><creatorcontrib>Vera, Ruth</creatorcontrib><creatorcontrib>Dominguez, Miguel Angel</creatorcontrib><creatorcontrib>Martinez, Enrique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arraras, Juan Ignacio</au><au>Manterola, Ana</au><au>Illarramendi, Jose Juan</au><au>Asin, Gemma</au><au>de la Cruz, Susana</au><au>Ibañez, Berta</au><au>Galbete, Arkaitz</au><au>Salgado, Esteban</au><au>Zarandona, Uxue</au><au>Vera, Ruth</au><au>Dominguez, Miguel Angel</au><au>Martinez, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up</atitle><jtitle>Breast (Edinburgh)</jtitle><addtitle>Breast</addtitle><date>2018-10</date><risdate>2018</risdate><volume>41</volume><spage>74</spage><epage>81</epage><pages>74-81</pages><issn>0960-9776</issn><eissn>1532-3080</eissn><abstract>This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups.
Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT.
Longitudinal changes in QL were assessed for the whole sample using linear mixed-effect models. Also assessed were differences in QL scores between axillary treatment groups (axillary node dissection ALND, sentinel lymph node biopsy SLNB, and no surgery) at the end of the follow-up (Anova or Kruskal-Wallis) and differences in the evolution of QL from baseline among these groups (linear regression models).
QL scores in the follow-up were high (>70/100 points) in most QL areas, with moderate limitations (>30) in sexual functioning and enjoyment. Five areas (pain, nausea/vomiting, financial impact, breast symptoms and IDDD) improved significantly (<6 points) in the follow-up.
The ALND group scored less for the future perspective item (15–20 points) in the follow-up than the other two axillary treatment groups. No differences between the pre-treatment and follow up assessments regarding treatment were found among the axillary treatment groups.
Our results suggest that early-stage breast cancer patients adapted well both to their disease and treatments over the follow-up period and to the administration of RT. There were few QL differences between the axillary treatment groups.
•QL in elderly early-stage breast cancer survivors treated with RT was high.•Limitations in sexuality areas were moderate.•QL 3 years after the end of RT was higher than pre-RT scores.•Patients who received axillary node dissection had less future perspective.•Patients adapted well to their disease and treatment.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30007271</pmid><doi>10.1016/j.breast.2018.06.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Axilla - pathology Axilla - surgery Breast cancer Breast Neoplasms - psychology Breast Neoplasms - radiotherapy Cancer Survivors - psychology Cancer Survivors - statistics & numerical data Elderly EORTC Female Follow-Up Studies Humans Lymph Node Excision - statistics & numerical data Lymphatic Metastasis Mastectomy - statistics & numerical data Middle Aged Quality of Life Radiotherapy Spain Surveys and Questionnaires Survivor |
| title | Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up |
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