Prospective investigation of applicability and the prognostic significance of bone marrow involvement in patients with neuroblastoma detected by quantitative reverse transcription PCR

Background Detection of bone marrow (BM) involvement in patients with neuroblastoma is crucial for staging and defining prognosis. Furthermore, the persistence of residual tumor cells in the BM is associated with an unfavorable outcome. Methods Expression of PHOX2B, TH, ELAVL4, and B4GALNT1 (GD2‐syn...

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Veröffentlicht in:	Pediatric blood & cancer 2018-11, Vol.65 (11), p.e27354-n/a
Hauptverfasser:	Druy, Alexander E., Shorikov, Egor V., Tsaur, Grigory A., Popov, Alexander M., Zaychikov, Artem N., Tuponogov, Sergey N., Saveliev, Leonid I., Tytgat, Godelieve A.M., Fechina, Larisa G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Bone marrow Bone Marrow - pathology Bone Neoplasms - diagnosis Bone Neoplasms - mortality Bone Neoplasms - secondary Chemotherapy Child Child, Preschool Female Hematology Homeodomain Proteins - analysis Humans Infant Infant, Newborn Kaplan-Meier Estimate Male Medical prognosis Neoplasm Staging - methods Neuroblastoma Neuroblastoma - mortality Neuroblastoma - pathology Oncology Pediatrics PHOX2B Phox2b protein Polymerase chain reaction Prognosis Prospective Studies Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Reverse transcription Risk groups Sensitivity and Specificity TH expression Transcription Factors - analysis Tumor cells Tyrosine 3-Monooxygenase - analysis
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