Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling

Glioblastoma Multiforme (GBM) is the most malignant and invasive tumor of the CNS. Although temozolomide (TMZ) has improved the survival, long-lasting responses have not been reported. Therefore, there is a need to develop improved treatments, one of which might be newly identified drugs which can b...

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Veröffentlicht in:	Toxicology in vitro 2018-10, Vol.52, p.306-313
Hauptverfasser:	Hanif, Farina, Perveen, Kahkashan, Malhi, Saima M., Jawed, Huma, Simjee, Shabana U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensives Apoptosis Bcl-2 protein Central nervous system Chemotherapy Drugs Glioblastoma Glioblastoma multiforme Growth inhibition Immunocytochemistry Polymerase chain reaction Temozolmide Temozolomide Tumors Verapamil
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