Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients
AimsTo determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC.MethodsWe retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018.ResultsThe fema...
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| Veröffentlicht in: | British journal of ophthalmology 2019-06, Vol.103 (6), p.725-729 |
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| creator | Ersoz, M Giray Arf, Serra Hocaoglu, Mumin Sayman Muslubas, Isil Karacorlu, Murat |
| description | AimsTo determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC.MethodsWe retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018.ResultsThe female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45–49 years. Women had two prevalence peaks, the higher at 55–59 years and the other at 45–49 years. Of these patients, 56.8% had unilateral disease, 42.1% had bilateral disease and 1.1% had only one eye. 671 (82.7%) patients had spectral domain optical coherence tomography (SD-OCT) images and 598 (73.7%) had enhanced depth choroidal images. Pigment epithelial detachment (PED) was detected in 763 (80.7%) of 945 eyes with SD-OCT images. Chronic cases were more likely to be bilateral and multifocal and to have PED (all p |
| doi_str_mv | 10.1136/bjophthalmol-2018-312431 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2070234320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070234320</sourcerecordid><originalsourceid>FETCH-LOGICAL-b453t-e5d28ce052a794e1afee11bbe49beccbd52df5b258b48c038a8c3a66a8a894c53</originalsourceid><addsrcrecordid>eNqNkU1u2zAQhYkiReO6vUIhoJts1HJI_dDZBUH6AwRoF-1aGFIjWK4kKiS98G18Fp-sYygJiqy64uPgezNDPiEykJ8AdPXZ7vy8TVscRj_kSoLJNahCwyuxgqIyXKo3F2IlpaxzgAouxdsYd3xVFdRvxKU-S1mrlZh-YuppSpnbYkCXKPQx9S5mOLUZ6z-nY8dlHyILHzLHbMDhdIwU_D6yzYfeB0r95GdM28M1O09HnHA4xD5mvssMQDYvU-I78brDIdL7x3Mtfn-5-3X7Lb__8fX77c19botSp5zKVhlHslRYbwoC7IgArKViY8k525aq7UqrSmML46Q2aJzGqkIWm8KVei2ulr5z8A97iqkZ--hoGHAiXrvhx0ulC60kox9foDu_D7w_U0pDbWTFf74WZqFc8DEG6po59COGQwOyOWfS_JtJc86kWTJh64fHAXs7UvtsfAqBAb0Adtz9f9u_V5WhxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2231780611</pqid></control><display><type>article</type><title>Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients</title><source>MEDLINE</source><source>PubMed Central</source><creator>Ersoz, M Giray ; Arf, Serra ; Hocaoglu, Mumin ; Sayman Muslubas, Isil ; Karacorlu, Murat</creator><creatorcontrib>Ersoz, M Giray ; Arf, Serra ; Hocaoglu, Mumin ; Sayman Muslubas, Isil ; Karacorlu, Murat</creatorcontrib><description>AimsTo determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC.MethodsWe retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018.ResultsThe female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45–49 years. Women had two prevalence peaks, the higher at 55–59 years and the other at 45–49 years. Of these patients, 56.8% had unilateral disease, 42.1% had bilateral disease and 1.1% had only one eye. 671 (82.7%) patients had spectral domain optical coherence tomography (SD-OCT) images and 598 (73.7%) had enhanced depth choroidal images. Pigment epithelial detachment (PED) was detected in 763 (80.7%) of 945 eyes with SD-OCT images. Chronic cases were more likely to be bilateral and multifocal and to have PED (all p<0.001). Subfoveal choroidal thickness (SFCT) did not differ between chronic and classic cases (p=0.74), but SFCT was greater in multifocal cases than unifocal cases (p<0.001). In multivariate regression analyses, older age of onset, longer duration of disease and hyperopia were positively associated with having chronic disease rather than classic disease, and myopia and thyroid hormone replacement were negatively associated. Steroid use, antidepressant or anxiolytic drug use, smoking, pregnancy and hyperopia were risk factors, and myopia was a protective factor for CSC.ConclusionThis is the largest case-control study of CSC to evaluate demographic morphological characteristics and risk factors. Multiple factors are associated with CSC.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2018-312431</identifier><identifier>PMID: 30002072</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age Distribution ; Age Factors ; Aged ; Atrophy ; Cardiovascular disease ; Case-Control Studies ; Central Serous Chorioretinopathy - diagnosis ; Central Serous Chorioretinopathy - epidemiology ; Choroid - pathology ; Family medical history ; Female ; Fluorescein Angiography - methods ; Follow-Up Studies ; Fundus Oculi ; Health risk assessment ; Humans ; Male ; Medical imaging ; Medical records ; Middle Aged ; Myopia ; Ophthalmology ; Population ; Prevalence ; Retina - pathology ; Retrospective Studies ; Risk Assessment ; Risk factors ; Sex Distribution ; Sex Factors ; Surgery ; Systemic diseases ; Tomography, Optical Coherence - methods ; Turkey - epidemiology ; Ulcers ; Visual Acuity ; Young Adult</subject><ispartof>British journal of ophthalmology, 2019-06, Vol.103 (6), p.725-729</ispartof><rights>Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b453t-e5d28ce052a794e1afee11bbe49beccbd52df5b258b48c038a8c3a66a8a894c53</citedby><cites>FETCH-LOGICAL-b453t-e5d28ce052a794e1afee11bbe49beccbd52df5b258b48c038a8c3a66a8a894c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30002072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ersoz, M Giray</creatorcontrib><creatorcontrib>Arf, Serra</creatorcontrib><creatorcontrib>Hocaoglu, Mumin</creatorcontrib><creatorcontrib>Sayman Muslubas, Isil</creatorcontrib><creatorcontrib>Karacorlu, Murat</creatorcontrib><title>Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AimsTo determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC.MethodsWe retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018.ResultsThe female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45–49 years. Women had two prevalence peaks, the higher at 55–59 years and the other at 45–49 years. Of these patients, 56.8% had unilateral disease, 42.1% had bilateral disease and 1.1% had only one eye. 671 (82.7%) patients had spectral domain optical coherence tomography (SD-OCT) images and 598 (73.7%) had enhanced depth choroidal images. Pigment epithelial detachment (PED) was detected in 763 (80.7%) of 945 eyes with SD-OCT images. Chronic cases were more likely to be bilateral and multifocal and to have PED (all p<0.001). Subfoveal choroidal thickness (SFCT) did not differ between chronic and classic cases (p=0.74), but SFCT was greater in multifocal cases than unifocal cases (p<0.001). In multivariate regression analyses, older age of onset, longer duration of disease and hyperopia were positively associated with having chronic disease rather than classic disease, and myopia and thyroid hormone replacement were negatively associated. Steroid use, antidepressant or anxiolytic drug use, smoking, pregnancy and hyperopia were risk factors, and myopia was a protective factor for CSC.ConclusionThis is the largest case-control study of CSC to evaluate demographic morphological characteristics and risk factors. Multiple factors are associated with CSC.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Central Serous Chorioretinopathy - diagnosis</subject><subject>Central Serous Chorioretinopathy - epidemiology</subject><subject>Choroid - pathology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Follow-Up Studies</subject><subject>Fundus Oculi</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical records</subject><subject>Middle Aged</subject><subject>Myopia</subject><subject>Ophthalmology</subject><subject>Population</subject><subject>Prevalence</subject><subject>Retina - pathology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Surgery</subject><subject>Systemic diseases</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Turkey - epidemiology</subject><subject>Ulcers</subject><subject>Visual Acuity</subject><subject>Young Adult</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1u2zAQhYkiReO6vUIhoJts1HJI_dDZBUH6AwRoF-1aGFIjWK4kKiS98G18Fp-sYygJiqy64uPgezNDPiEykJ8AdPXZ7vy8TVscRj_kSoLJNahCwyuxgqIyXKo3F2IlpaxzgAouxdsYd3xVFdRvxKU-S1mrlZh-YuppSpnbYkCXKPQx9S5mOLUZ6z-nY8dlHyILHzLHbMDhdIwU_D6yzYfeB0r95GdM28M1O09HnHA4xD5mvssMQDYvU-I78brDIdL7x3Mtfn-5-3X7Lb__8fX77c19botSp5zKVhlHslRYbwoC7IgArKViY8k525aq7UqrSmML46Q2aJzGqkIWm8KVei2ulr5z8A97iqkZ--hoGHAiXrvhx0ulC60kox9foDu_D7w_U0pDbWTFf74WZqFc8DEG6po59COGQwOyOWfS_JtJc86kWTJh64fHAXs7UvtsfAqBAb0Adtz9f9u_V5WhxQ</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Ersoz, M Giray</creator><creator>Arf, Serra</creator><creator>Hocaoglu, Mumin</creator><creator>Sayman Muslubas, Isil</creator><creator>Karacorlu, Murat</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients</title><author>Ersoz, M Giray ; Arf, Serra ; Hocaoglu, Mumin ; Sayman Muslubas, Isil ; Karacorlu, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b453t-e5d28ce052a794e1afee11bbe49beccbd52df5b258b48c038a8c3a66a8a894c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Central Serous Chorioretinopathy - diagnosis</topic><topic>Central Serous Chorioretinopathy - epidemiology</topic><topic>Choroid - pathology</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Follow-Up Studies</topic><topic>Fundus Oculi</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical records</topic><topic>Middle Aged</topic><topic>Myopia</topic><topic>Ophthalmology</topic><topic>Population</topic><topic>Prevalence</topic><topic>Retina - pathology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Surgery</topic><topic>Systemic diseases</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Turkey - epidemiology</topic><topic>Ulcers</topic><topic>Visual Acuity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ersoz, M Giray</creatorcontrib><creatorcontrib>Arf, Serra</creatorcontrib><creatorcontrib>Hocaoglu, Mumin</creatorcontrib><creatorcontrib>Sayman Muslubas, Isil</creatorcontrib><creatorcontrib>Karacorlu, Murat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ersoz, M Giray</au><au>Arf, Serra</au><au>Hocaoglu, Mumin</au><au>Sayman Muslubas, Isil</au><au>Karacorlu, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>103</volume><issue>6</issue><spage>725</spage><epage>729</epage><pages>725-729</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>AimsTo determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC.MethodsWe retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018.ResultsThe female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45–49 years. Women had two prevalence peaks, the higher at 55–59 years and the other at 45–49 years. Of these patients, 56.8% had unilateral disease, 42.1% had bilateral disease and 1.1% had only one eye. 671 (82.7%) patients had spectral domain optical coherence tomography (SD-OCT) images and 598 (73.7%) had enhanced depth choroidal images. Pigment epithelial detachment (PED) was detected in 763 (80.7%) of 945 eyes with SD-OCT images. Chronic cases were more likely to be bilateral and multifocal and to have PED (all p<0.001). Subfoveal choroidal thickness (SFCT) did not differ between chronic and classic cases (p=0.74), but SFCT was greater in multifocal cases than unifocal cases (p<0.001). In multivariate regression analyses, older age of onset, longer duration of disease and hyperopia were positively associated with having chronic disease rather than classic disease, and myopia and thyroid hormone replacement were negatively associated. Steroid use, antidepressant or anxiolytic drug use, smoking, pregnancy and hyperopia were risk factors, and myopia was a protective factor for CSC.ConclusionThis is the largest case-control study of CSC to evaluate demographic morphological characteristics and risk factors. Multiple factors are associated with CSC.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30002072</pmid><doi>10.1136/bjophthalmol-2018-312431</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Distribution Age Factors Aged Atrophy Cardiovascular disease Case-Control Studies Central Serous Chorioretinopathy - diagnosis Central Serous Chorioretinopathy - epidemiology Choroid - pathology Family medical history Female Fluorescein Angiography - methods Follow-Up Studies Fundus Oculi Health risk assessment Humans Male Medical imaging Medical records Middle Aged Myopia Ophthalmology Population Prevalence Retina - pathology Retrospective Studies Risk Assessment Risk factors Sex Distribution Sex Factors Surgery Systemic diseases Tomography, Optical Coherence - methods Turkey - epidemiology Ulcers Visual Acuity Young Adult |
| title | Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients |
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