SETTING SAFE ACUTE EXPOSURE LIMITS FOR HALON REPLACEMENT CHEMICALS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING

Most proposed replacements for Halon 1301 as a fire suppressant are halogenated hydrocarbons. The acute toxic endpoint of concern for these agents is cardiac sensitization. An approach is described that links the cardiac endpoint as assessed in dogs to a target arterial concentration in humans. Link...

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Veröffentlicht in:	Inhalation toxicology 2000-08, Vol.12 (8), p.751-763
1. Verfasser:	Allen Vinegar, Gary W. Jepson, Mark Cisneros, Reva Rubenstein, William J. Brock
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromochlorofluorocarbons Chlorofluorocarbons, Methane - pharmacokinetics Chlorofluorocarbons, Methane - toxicity Dogs Epinephrine - administration & dosage Flame Retardants - pharmacokinetics Flame Retardants - toxicity Fluorocarbons - pharmacokinetics Fluorocarbons - toxicity Heart Rate - drug effects Humans Hydrocarbons, Fluorinated - pharmacokinetics Hydrocarbons, Fluorinated - pharmacology Hydrocarbons, Fluorinated - toxicity Hydrocarbons, Halogenated - pharmacokinetics Hydrocarbons, Halogenated - toxicity Inhalation Exposure Models, Biological Monte Carlo Method No-Observed-Adverse-Effect Level Solubility Toxicity Tests, Acute
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