Pharmacokinetic Evaluation of Emtricitabine in Combination With Other Nucleoside Antivirals in Healthy Volunteers

Emtricitabine is a potent nucleoside reverse transcriptase inhibitor approved as a once‐daily drug in combination with other antiretroviral agents for the treatment of HIV infection. Several phase I studies were conducted in healthy volunteers over the course of clinical development to evaluate whet...

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Veröffentlicht in:	Journal of clinical pharmacology 2007-07, Vol.47 (7), p.877-889
Hauptverfasser:	Zong, Jian, Chittick, Gregory E., Wang, Laurene H., Hui, James, Begley, John A., Blum, M. Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - administration & dosage 2-Aminopurine - analogs & derivatives 2-Aminopurine - blood 2-Aminopurine - pharmacokinetics 2-Aminopurine - therapeutic use Adolescent Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - blood Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use antivirals Area Under Curve Cross-Over Studies Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - blood Deoxycytidine - pharmacokinetics Deoxycytidine - therapeutic use Dosage and administration Drug Interactions Drug therapy Drug Therapy, Combination Emtricitabine famciclovir Female HIV infection Human immunodeficiency virus Humans Male Middle Aged nucleoside reverse transcriptase inhibitor nucleosides penciclovir Pharmacokinetics Properties Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - blood Reverse Transcriptase Inhibitors - pharmacokinetics Reverse Transcriptase Inhibitors - therapeutic use stavudine Stavudine - administration & dosage Stavudine - blood Stavudine - pharmacokinetics Stavudine - therapeutic use zidovudine Zidovudine - administration & dosage Zidovudine - blood Zidovudine - pharmacokinetics Zidovudine - therapeutic use
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