Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally thought to lead to detoxication of xenobiotics, the reactions can also produce reactive intermediates that can react with cellular m...

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Veröffentlicht in:	Chemical research in toxicology 2008-01, Vol.21 (1), p.189-205
Hauptverfasser:	Hollenberg, Paul F, Kent, Ute M, Bumpus, Namandjé N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Animals Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Kinetics Structure-Activity Relationship Xenobiotics - metabolism
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