Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other Dementias
Cerebrospinal fluid (CSF) biological markers may be of valuable help in the diagnosis of dementia. The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and contro...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2006-01, Vol.21 (1), p.9-15 |
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| creator | Blasko, Imrich Lederer, Wolfgang Oberbauer, Harald Walch, Thomas Kemmler, Georg Hinterhuber, Hartmann Marksteiner, Josef Humpel, Christian |
| description | Cerebrospinal fluid (CSF) biological markers may be of valuable help in the diagnosis of dementia. The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and control patients without any neuropsychiatric disease. The study was performed using β-amyloid 1–42 (Aβ42), total tau and phosphorylated tau-181 (P-tau181) as core markers. The ratio P-tau181/Aβ42 could significantly distinguish AD patients from all other diagnostic subgroups. CSF levels of 5 growth factors (HGF, GDNF, VEGF, BDNF, FGF-2) and 3 cytokines/chemokines (TNF-α, TGF-β 1 , MIP-1α) did not significantly differentiate between the studied groups. However, depending on the degree of neurodegeneration (as expressed by the ratio P-tau181/Aβ42), patients with AD displayed significantly increased CSF levels of nerve growth factor (NGF) as compared to healthy controls. CSF levels of monocyte chemoattractant protein 1 (MCP-1) were found to be significantly increased with age in all groups but did not distinguish AD patients from healthy controls. The results confirmed the suitability of the ratio P-tau181/Aβ42 for the diagnosis of AD, while CSF levels of NGF and MCP-1 are less specific and reliable for AD. It is suggested that the increase in NGF depends on the extent of neurodegeneration of the AD type and the increase in MCP-1 on age. |
| doi_str_mv | 10.1159/000089137 |
| format | Article |
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The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and control patients without any neuropsychiatric disease. The study was performed using β-amyloid 1–42 (Aβ42), total tau and phosphorylated tau-181 (P-tau181) as core markers. The ratio P-tau181/Aβ42 could significantly distinguish AD patients from all other diagnostic subgroups. CSF levels of 5 growth factors (HGF, GDNF, VEGF, BDNF, FGF-2) and 3 cytokines/chemokines (TNF-α, TGF-β 1 , MIP-1α) did not significantly differentiate between the studied groups. However, depending on the degree of neurodegeneration (as expressed by the ratio P-tau181/Aβ42), patients with AD displayed significantly increased CSF levels of nerve growth factor (NGF) as compared to healthy controls. CSF levels of monocyte chemoattractant protein 1 (MCP-1) were found to be significantly increased with age in all groups but did not distinguish AD patients from healthy controls. The results confirmed the suitability of the ratio P-tau181/Aβ42 for the diagnosis of AD, while CSF levels of NGF and MCP-1 are less specific and reliable for AD. It is suggested that the increase in NGF depends on the extent of neurodegeneration of the AD type and the increase in MCP-1 on age.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000089137</identifier><identifier>PMID: 16244482</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Alcohol Amnestic Disorder - cerebrospinal fluid ; Alcohol Amnestic Disorder - diagnosis ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - diagnosis ; Amyloid beta-Peptides - cerebrospinal fluid ; Biological and medical sciences ; Biomarkers - cerebrospinal fluid ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Chemokines - cerebrospinal fluid ; Cytokines - cerebrospinal fluid ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia - cerebrospinal fluid ; Dementia - diagnosis ; Depressive Disorder, Major - cerebrospinal fluid ; Depressive Disorder, Major - diagnosis ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Growth Substances - cerebrospinal fluid ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Neurology ; Original Research Article ; Peptide Fragments - cerebrospinal fluid ; Phosphorylation ; Predictive Value of Tests ; Reference Values ; tau Proteins - cerebrospinal fluid ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Dementia and geriatric cognitive disorders, 2006-01, Vol.21 (1), p.9-15</ispartof><rights>2006 S. Karger AG, Basel</rights><rights>2006 INIST-CNRS</rights><rights>Copyright 2006 S. Karger AG, Basel.</rights><rights>Copyright (c) 2006 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-ae49b9d9516074b62647062793ce45386217ba85976f71796766237f7c2f1d3b3</citedby><cites>FETCH-LOGICAL-c391t-ae49b9d9516074b62647062793ce45386217ba85976f71796766237f7c2f1d3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2427,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17422589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16244482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blasko, Imrich</creatorcontrib><creatorcontrib>Lederer, Wolfgang</creatorcontrib><creatorcontrib>Oberbauer, Harald</creatorcontrib><creatorcontrib>Walch, Thomas</creatorcontrib><creatorcontrib>Kemmler, Georg</creatorcontrib><creatorcontrib>Hinterhuber, Hartmann</creatorcontrib><creatorcontrib>Marksteiner, Josef</creatorcontrib><creatorcontrib>Humpel, Christian</creatorcontrib><title>Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other Dementias</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Cerebrospinal fluid (CSF) biological markers may be of valuable help in the diagnosis of dementia. The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and control patients without any neuropsychiatric disease. The study was performed using β-amyloid 1–42 (Aβ42), total tau and phosphorylated tau-181 (P-tau181) as core markers. The ratio P-tau181/Aβ42 could significantly distinguish AD patients from all other diagnostic subgroups. CSF levels of 5 growth factors (HGF, GDNF, VEGF, BDNF, FGF-2) and 3 cytokines/chemokines (TNF-α, TGF-β 1 , MIP-1α) did not significantly differentiate between the studied groups. However, depending on the degree of neurodegeneration (as expressed by the ratio P-tau181/Aβ42), patients with AD displayed significantly increased CSF levels of nerve growth factor (NGF) as compared to healthy controls. CSF levels of monocyte chemoattractant protein 1 (MCP-1) were found to be significantly increased with age in all groups but did not distinguish AD patients from healthy controls. The results confirmed the suitability of the ratio P-tau181/Aβ42 for the diagnosis of AD, while CSF levels of NGF and MCP-1 are less specific and reliable for AD. It is suggested that the increase in NGF depends on the extent of neurodegeneration of the AD type and the increase in MCP-1 on age.</description><subject>Aged</subject><subject>Alcohol Amnestic Disorder - cerebrospinal fluid</subject><subject>Alcohol Amnestic Disorder - diagnosis</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Amyloid beta-Peptides - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. 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The aim of the present study was to evaluate CSF levels of 13 potential biomarkers in patients with Alzheimer’s disease (AD), frontotemporal lobe dementia, alcohol dementia, major depression and control patients without any neuropsychiatric disease. The study was performed using β-amyloid 1–42 (Aβ42), total tau and phosphorylated tau-181 (P-tau181) as core markers. The ratio P-tau181/Aβ42 could significantly distinguish AD patients from all other diagnostic subgroups. CSF levels of 5 growth factors (HGF, GDNF, VEGF, BDNF, FGF-2) and 3 cytokines/chemokines (TNF-α, TGF-β 1 , MIP-1α) did not significantly differentiate between the studied groups. However, depending on the degree of neurodegeneration (as expressed by the ratio P-tau181/Aβ42), patients with AD displayed significantly increased CSF levels of nerve growth factor (NGF) as compared to healthy controls. CSF levels of monocyte chemoattractant protein 1 (MCP-1) were found to be significantly increased with age in all groups but did not distinguish AD patients from healthy controls. The results confirmed the suitability of the ratio P-tau181/Aβ42 for the diagnosis of AD, while CSF levels of NGF and MCP-1 are less specific and reliable for AD. It is suggested that the increase in NGF depends on the extent of neurodegeneration of the AD type and the increase in MCP-1 on age.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16244482</pmid><doi>10.1159/000089137</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Dementia and geriatric cognitive disorders, 2006-01, Vol.21 (1), p.9-15 |
| issn | 1420-8008 1421-9824 |
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| subjects | Aged Alcohol Amnestic Disorder - cerebrospinal fluid Alcohol Amnestic Disorder - diagnosis Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Amyloid beta-Peptides - cerebrospinal fluid Biological and medical sciences Biomarkers - cerebrospinal fluid Blood and lymphatic vessels Cardiology. Vascular system Chemokines - cerebrospinal fluid Cytokines - cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - cerebrospinal fluid Dementia - diagnosis Depressive Disorder, Major - cerebrospinal fluid Depressive Disorder, Major - diagnosis Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Growth Substances - cerebrospinal fluid Human viral diseases Humans Infectious diseases Medical sciences Neurology Original Research Article Peptide Fragments - cerebrospinal fluid Phosphorylation Predictive Value of Tests Reference Values tau Proteins - cerebrospinal fluid Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Measurement of Thirteen Biological Markers in CSF of Patients with Alzheimer’s Disease and Other Dementias |
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