Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

Anti-inflammatory strategies have attracted much interest for their potential to prevent further deterioration of Parkinson's disease. Recent experimental and clinical evidence indicate that statins - extensively used in medical practice as effective lipid-lowering agents - have also anti-infla...

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Veröffentlicht in:	Journal of neurochemistry 2008-04, Vol.105 (2), p.445-459
Hauptverfasser:	Hernández-Romero, María del Carmen, Argüelles, Sandro, Villarán, Ruth F, de Pablos, Rocío M, Delgado-Cortés, María José, Santiago, Marti, Herrera, Antonio J, Cano, Josefina, Machado, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Arachidonic Acids - genetics Arachidonic Acids - metabolism Biochemistry Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism dopaminergic neurodegeneration Drug Interactions Gene Expression Regulation - drug effects inflammation Inflammation - chemically induced Inflammation - prevention & control Inflammatory diseases Male Medical sciences Nerve Degeneration - chemically induced Nerve Degeneration - prevention & control Nerve Tissue Proteins - metabolism Nervous system (semeiology, syndromes) Nervous system as a whole Neurology neuroprotection Neurotransmitters Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Parkinson's disease Rats Rats, Wistar simvastatin Simvastatin - pharmacology Statins substantia nigra Substantia Nigra - drug effects Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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