A twin study of smoking, nicotine dependence, and major depression in men

This study examined the nature of the relationship among lifetime major depression, smoking, and nicotine dependence. Subjects were 8,169 male twins from the Vietnam Era Twin Registry. Biometrical modeling demonstrated a genetic influence on daily smoking, nicotine dependence, and major depression,...

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Veröffentlicht in:Nicotine & tobacco research 2008-01, Vol.10 (1), p.97-108
Hauptverfasser: Lyons, Michael, Hitsman, Brian, Xian, Hong, Panizzon, Matthew S., Jerskey, Beth A., Santangelo, Susan, Grant, Michael D., Rende, Richard, Eisen, Seth, Eaves, Lindon, Tsuang, Ming T.
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container_end_page 108
container_issue 1
container_start_page 97
container_title Nicotine & tobacco research
container_volume 10
creator Lyons, Michael
Hitsman, Brian
Xian, Hong
Panizzon, Matthew S.
Jerskey, Beth A.
Santangelo, Susan
Grant, Michael D.
Rende, Richard
Eisen, Seth
Eaves, Lindon
Tsuang, Ming T.
description This study examined the nature of the relationship among lifetime major depression, smoking, and nicotine dependence. Subjects were 8,169 male twins from the Vietnam Era Twin Registry. Biometrical modeling demonstrated a genetic influence on daily smoking, nicotine dependence, and major depression, and a family environmental influence on daily smoking. Genetic factors influencing nicotine dependence also strongly influenced major depression. We also compared probands with a history of major depression (n=398) from pairs discordant for major depression, their nondepressed cotwins (n=364), and controls (n=1,863) on a number of secondary smoking outcomes. Major depression was associated with current daily smoking and certain nicotine withdrawal symptoms. Individuals with a familial vulnerability for major depression, even without a personal history of major depression, were more likely to smoke despite a serious illness and to report nervousness, restlessness, difficulty concentrating, and depressed mood during past quit attempts. Among the 237 monozygotic pairs discordant for major depression, depressed probands were more likely to have a lifetime history of nicotine dependence than were cotwins. Findings extend Kendler and colleague's (1993) study of female twins by demonstrating in men that shared genetic factors predispose not only to major depression and daily smoking but also to major depression and nicotine dependence.
doi_str_mv 10.1080/14622200701705332
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source Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection
subjects Adult
Case-Control Studies
Comorbidity
Depressive Disorder - epidemiology
Depressive Disorder - genetics
Diseases in Twins - epidemiology
Diseases in Twins - genetics
Humans
Life Style
Male
Middle Aged
Smoking - epidemiology
Smoking - genetics
Social Environment
Tobacco Use Disorder - epidemiology
Tobacco Use Disorder - genetics
Twins, Dizygotic
Twins, Monozygotic
United States - epidemiology
title A twin study of smoking, nicotine dependence, and major depression in men
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