Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats
Effect of different Ca 2+ concentrations in the bathing solution [Ca 2+ ] o on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experiment...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-07, Vol.165 (3), p.315-318 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 318 |
|---|---|
| container_issue | 3 |
| container_start_page | 315 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 165 |
| creator | Protsenko, Yu. L. Kuznetsov, D. A. Lisin, R. V. Lukin, O. N. Balakin, A. A. |
| description | Effect of different Ca
2+
concentrations in the bathing solution [Ca
2+
]
o
on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experimental animals, the increase in calcium concentration was followed by a decrease in the myocardium slow response intensity. We revealed a complementary relationship between the current and medium-term systems of myocardial contractility regulation by the length of the myocardium aimed at the maintenance of the constant level during adaptation to the load. Slow responses of the hypertrophied rat heart myocardium were suppressed in comparison with those in the healthy myocardium and their intensity did not depend on animal sex. |
| doi_str_mv | 10.1007/s10517-018-4158-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2068909528</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A549718747</galeid><sourcerecordid>A549718747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-4eadf585439788ebf27523ccf80d0a6664d50d3ae1f8a9ab98a143636806bf793</originalsourceid><addsrcrecordid>eNp1ks1u1DAUhS0EokPhAdggS0iomxQ7cRJ7WY06nUqtQMPP1vI41zOukjjYjlBegyfGmSmUIpAX_vvOsa99EHpNyTklpH4fKClpnRHKM0ZLnk1P0IKWdZHxPKdP0YIkKGOc8xP0IoS7eUoq-hyd5EIIzgq-QD8ujQEdsTN4qVptxw67Hn9q3Xe8cl4D3kAYXB8gYNvj6-BaFaHBG7vbR_wV-uitbgF_9DAor6JN6Oy1BtXG_YRV3-D1NICP3g17m5S3k9PKN_NByfBWJfEMraCbhxsVw0v0zKg2wKv7_hR9WV1-Xq6zmw9X18uLm0yzmsSMgWpMyUtWiJpz2Jq8LvNCa8NJQ1RVVawpSVMooIYrobaCK8qKqqg4qbamFsUpOjv6Dt59GyFE2dmgoW1VD24MMicVF0SUOU_o27_QOzf6Pt3uQFGRGPZA7VIp0vbGRa_0bCovSiZqymtWJ-r8H1RqDXRWux6MTeuPBO_-EOwPL5v-YTw89mOQHkHtXQgejBy87ZSfJCVyDow8BkamwMg5MHJKmjf3lY3bDprfil8JSUB-BELa6nfgH0r_v-tPBynKEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068192834</pqid></control><display><type>article</type><title>Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats</title><source>SpringerLink Journals - AutoHoldings</source><creator>Protsenko, Yu. L. ; Kuznetsov, D. A. ; Lisin, R. V. ; Lukin, O. N. ; Balakin, A. A.</creator><creatorcontrib>Protsenko, Yu. L. ; Kuznetsov, D. A. ; Lisin, R. V. ; Lukin, O. N. ; Balakin, A. A.</creatorcontrib><description>Effect of different Ca
2+
concentrations in the bathing solution [Ca
2+
]
o
on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experimental animals, the increase in calcium concentration was followed by a decrease in the myocardium slow response intensity. We revealed a complementary relationship between the current and medium-term systems of myocardial contractility regulation by the length of the myocardium aimed at the maintenance of the constant level during adaptation to the load. Slow responses of the hypertrophied rat heart myocardium were suppressed in comparison with those in the healthy myocardium and their intensity did not depend on animal sex.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4158-y</identifier><identifier>PMID: 29998438</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Calcium ; Calcium (extracellular) ; Cell Biology ; Contraction ; Internal Medicine ; Isometric ; Laboratory Medicine ; Muscle contraction ; Myocardium ; Pathology ; Rodents ; Ventricle</subject><ispartof>Bulletin of experimental biology and medicine, 2018-07, Vol.165 (3), p.315-318</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-4eadf585439788ebf27523ccf80d0a6664d50d3ae1f8a9ab98a143636806bf793</citedby><cites>FETCH-LOGICAL-c470t-4eadf585439788ebf27523ccf80d0a6664d50d3ae1f8a9ab98a143636806bf793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4158-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4158-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29998438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Protsenko, Yu. L.</creatorcontrib><creatorcontrib>Kuznetsov, D. A.</creatorcontrib><creatorcontrib>Lisin, R. V.</creatorcontrib><creatorcontrib>Lukin, O. N.</creatorcontrib><creatorcontrib>Balakin, A. A.</creatorcontrib><title>Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Effect of different Ca
2+
concentrations in the bathing solution [Ca
2+
]
o
on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experimental animals, the increase in calcium concentration was followed by a decrease in the myocardium slow response intensity. We revealed a complementary relationship between the current and medium-term systems of myocardial contractility regulation by the length of the myocardium aimed at the maintenance of the constant level during adaptation to the load. Slow responses of the hypertrophied rat heart myocardium were suppressed in comparison with those in the healthy myocardium and their intensity did not depend on animal sex.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Calcium (extracellular)</subject><subject>Cell Biology</subject><subject>Contraction</subject><subject>Internal Medicine</subject><subject>Isometric</subject><subject>Laboratory Medicine</subject><subject>Muscle contraction</subject><subject>Myocardium</subject><subject>Pathology</subject><subject>Rodents</subject><subject>Ventricle</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1ks1u1DAUhS0EokPhAdggS0iomxQ7cRJ7WY06nUqtQMPP1vI41zOukjjYjlBegyfGmSmUIpAX_vvOsa99EHpNyTklpH4fKClpnRHKM0ZLnk1P0IKWdZHxPKdP0YIkKGOc8xP0IoS7eUoq-hyd5EIIzgq-QD8ujQEdsTN4qVptxw67Hn9q3Xe8cl4D3kAYXB8gYNvj6-BaFaHBG7vbR_wV-uitbgF_9DAor6JN6Oy1BtXG_YRV3-D1NICP3g17m5S3k9PKN_NByfBWJfEMraCbhxsVw0v0zKg2wKv7_hR9WV1-Xq6zmw9X18uLm0yzmsSMgWpMyUtWiJpz2Jq8LvNCa8NJQ1RVVawpSVMooIYrobaCK8qKqqg4qbamFsUpOjv6Dt59GyFE2dmgoW1VD24MMicVF0SUOU_o27_QOzf6Pt3uQFGRGPZA7VIp0vbGRa_0bCovSiZqymtWJ-r8H1RqDXRWux6MTeuPBO_-EOwPL5v-YTw89mOQHkHtXQgejBy87ZSfJCVyDow8BkamwMg5MHJKmjf3lY3bDprfil8JSUB-BELa6nfgH0r_v-tPBynKEw</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Protsenko, Yu. L.</creator><creator>Kuznetsov, D. A.</creator><creator>Lisin, R. V.</creator><creator>Lukin, O. N.</creator><creator>Balakin, A. A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats</title><author>Protsenko, Yu. L. ; Kuznetsov, D. A. ; Lisin, R. V. ; Lukin, O. N. ; Balakin, A. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-4eadf585439788ebf27523ccf80d0a6664d50d3ae1f8a9ab98a143636806bf793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Calcium (extracellular)</topic><topic>Cell Biology</topic><topic>Contraction</topic><topic>Internal Medicine</topic><topic>Isometric</topic><topic>Laboratory Medicine</topic><topic>Muscle contraction</topic><topic>Myocardium</topic><topic>Pathology</topic><topic>Rodents</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Protsenko, Yu. L.</creatorcontrib><creatorcontrib>Kuznetsov, D. A.</creatorcontrib><creatorcontrib>Lisin, R. V.</creatorcontrib><creatorcontrib>Lukin, O. N.</creatorcontrib><creatorcontrib>Balakin, A. A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Protsenko, Yu. L.</au><au>Kuznetsov, D. A.</au><au>Lisin, R. V.</au><au>Lukin, O. N.</au><au>Balakin, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>165</volume><issue>3</issue><spage>315</spage><epage>318</epage><pages>315-318</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Effect of different Ca
2+
concentrations in the bathing solution [Ca
2+
]
o
on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experimental animals, the increase in calcium concentration was followed by a decrease in the myocardium slow response intensity. We revealed a complementary relationship between the current and medium-term systems of myocardial contractility regulation by the length of the myocardium aimed at the maintenance of the constant level during adaptation to the load. Slow responses of the hypertrophied rat heart myocardium were suppressed in comparison with those in the healthy myocardium and their intensity did not depend on animal sex.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29998438</pmid><doi>10.1007/s10517-018-4158-y</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2018-07, Vol.165 (3), p.315-318 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2068909528 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Calcium Calcium (extracellular) Cell Biology Contraction Internal Medicine Isometric Laboratory Medicine Muscle contraction Myocardium Pathology Rodents Ventricle |
| title | Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T15%3A11%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Calcium%20on%20Slow%20Force%20Responses%20in%20Isolated%20Right%20Ventricle%20Preparations%20of%20Healthy%20and%20Hypertrophied%20Myocardium%20in%20Male%20and%20Female%20Rats&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Protsenko,%20Yu.%20L.&rft.date=2018-07-01&rft.volume=165&rft.issue=3&rft.spage=315&rft.epage=318&rft.pages=315-318&rft.issn=0007-4888&rft.eissn=1573-8221&rft_id=info:doi/10.1007/s10517-018-4158-y&rft_dat=%3Cgale_proqu%3EA549718747%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2068192834&rft_id=info:pmid/29998438&rft_galeid=A549718747&rfr_iscdi=true |