Inhibition of functional HER family members increases the sensitivity to docetaxel in human ovarian cancer cell lines

Human epidermal growth factor (HER) family-targeted therapy combined with standard cytotoxic agents might improve the treatment of ovarian cancer. Human ovarian cancer cell lines OVCAR-3, IGROV-1, and SKOV-3 with differential EGFR, HER2, and HER3 expression levels were used to study whether EGFR-dir...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Anti-cancer drugs 2009-07, Vol.20 (6), p.450-460
Hauptverfasser:	Bijman, Marcel N.A, van Berkel, Maria P.A, Kok, Mirjam, Janmaat, Maarten L, Boven, Epie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects Drug Synergism Enzyme Activation Female Humans Inhibitory Concentration 50 Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-3 - antagonists & inhibitors Taxoids - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!