γ-Secretase Inhibitor Reduces Allergic Pulmonary Inflammation by Modulating Th1 and Th2 Responses

Gamma-secretase inhibitor (GSI) has been used to effectively block Notch signaling, which is implicated in the differentiation and functional regulation of T helper (Th) effector cells. In asthma, a subset of CD4(+) T cells is believed to initiate and perpetuate the disease. The aim of this study wa...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2009-05, Vol.179 (10), p.875-882
Hauptverfasser:	JIN HYUN KANG, BYUNG SOO KIM, TAE GI UHM, LEE, Shin-Hwa, GAP RYOL LEE, PARK, Choon-Sik, II YUP CHUNG
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - immunology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cytokines - biosynthesis Cytokines - immunology Drug Synergism Eosinophilia - drug therapy Eosinophilia - enzymology Eosinophilia - immunology GATA3 Transcription Factor - biosynthesis Intensive care medicine Male Medical sciences Mice Mice, Inbred BALB C NF-kappa B - antagonists & inhibitors NF-kappa B - immunology Oligopeptides - pharmacology Ovalbumin - administration & dosage Ovalbumin - immunology Pneumology Pneumonia - drug therapy Pneumonia - enzymology Pneumonia - immunology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Receptors, Notch - metabolism Respiratory Hypersensitivity - drug therapy Respiratory Hypersensitivity - enzymology Respiratory Hypersensitivity - immunology Signal Transduction - drug effects Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology
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