Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9

Fraxini Cortex (also known as Qinpi, QP) has been used for the treatment of hyperuricemia with a significant difference on efficacy of QP from different regions. However, it`s still unknown whether proportion of components is the key and why same kind of herbs have different therapeutic effects. In...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-10, Vol.106, p.434-442
Hauptverfasser:	Zhou, Yuanli, Zhang, Xuanguo, Li, Chao, Yuan, Xin, Han, Lihua, Li, Zheng, Tan, Xiaobin, Song, Jie, Wang, Gang, Jia, Xiaobin, Feng, Liang, Qiao, Xiting, Liu, Jiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anion Transport Proteins - genetics Anion Transport Proteins - metabolism Biomarkers - blood Biomarkers - urine Blood Urea Nitrogen Coumarins - analysis Coumarins - pharmacology Creatinine - urine Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - pharmacology Esculin - analysis Esculin - pharmacology Fraxini Cortex GLUT9 Gout Suppressants - analysis Gout Suppressants - pharmacology Hyperuricemia Hyperuricemia - drug therapy Hyperuricemia - genetics Hyperuricemia - metabolism Hyperuricemia - physiopathology Kidney - drug effects Kidney - metabolism Kidney - physiopathology Male Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Rats, Sprague-Dawley Recovery of Function Structural proportion of components Umbelliferones - analysis Umbelliferones - pharmacology URAT1 Uric Acid - blood Uric Acid - metabolism Uric Acid - urine
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