Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism

Secreted amyloid precursor protein-α (sAPPα) is a neuroprotective and neurotrophic protein derived from the parent APP molecule. We have shown that sAPPα enhances long-term potentiation in vivo and can restore spatial memory in rats whose endogenous sAPPα production is impaired. These observations i...

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