Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a foo...
Gespeichert in:
| Veröffentlicht in: | Journal of biophotonics 2018-10, Vol.11 (10), p.e201800193-n/a |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 10 |
| container_start_page | e201800193 |
| container_title | Journal of biophotonics |
| container_volume | 11 |
| creator | Sancho‐Durá, Juan Zinoviev, Kirill Lloret‐Soler, Juan Rubio‐Guviernau, Jose Luis Margallo‐Balbás, Eduardo Drexler, Wolfgang |
| description | A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage Micro Electro‐Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm3, achieves an isotropic resolution of ~11 μm in tissue, −93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery‐powered device has a weight of 3 kg in a tablet format, enabling point‐of‐care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient‐centered diagnostic imaging workflow.
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy is presented. The instrument is enabled by a dedicated planar lightwave circuit (1.1 × 19.5 mm2 footprint) providing akinetic axial OCT scanning. The OCT engine (80 × 27 × 14 mm3 in volume), achieves ~11 μm of isotropic resolution in tissue, −93 dB sensitivity, 12 mm field of view, and 2.8 mm axial scanning range in air. |
| doi_str_mv | 10.1002/jbio.201800193 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2068343549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2117045903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3733-eff4e72f7df8e0bd250c63ee10f2e5dde399a0b6fa4ddb4375b8a1292f703bbc3</originalsourceid><addsrcrecordid>eNqFkb1uFDEUhS0EIiHQUiJLNDS7XNvz5xIiIEGR0oBEZ_nnetfLzHiwZxRtR8ED8Iw8CV5tWCQaGl_r-DtHVz6EPGewZgD89c6EuObAOgAmxQNyzrqmWkFTdQ9Pd_HljDzJeQfQgKjFY3LGpZS85c05-XGlR7fF3tFh6efw6_vPITrd0zDoTRg31MdEpxjGubxEXw6rE9L8NYzUBb0ZYw6ZGp3R0ThSXXScg6XFgJuk54M8FSEfRwm2cYsJR4t0jkMszLTdPyWPvO4zPrufF-Tz-3efLq9WN7cfri_f3KysaIVYofcVtty3zncIxvEabCMQGXiOtXMopNRgGq8r50wl2tp0mnFZHCCMseKCvDrmTil-WzDPagjZYt_rEeOSFYemE5WoK1nQl_-gu7iksWynOGMtVLUEUaj1kbIp5pzQqymVn0t7xUAd-lGHftSpn2J4cR-7mAHdCf9TSAHkEbgLPe7_E6c-vr2-_Rv-G9pcor0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2117045903</pqid></control><display><type>article</type><title>Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Sancho‐Durá, Juan ; Zinoviev, Kirill ; Lloret‐Soler, Juan ; Rubio‐Guviernau, Jose Luis ; Margallo‐Balbás, Eduardo ; Drexler, Wolfgang</creator><creatorcontrib>Sancho‐Durá, Juan ; Zinoviev, Kirill ; Lloret‐Soler, Juan ; Rubio‐Guviernau, Jose Luis ; Margallo‐Balbás, Eduardo ; Drexler, Wolfgang</creatorcontrib><description>A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage Micro Electro‐Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm3, achieves an isotropic resolution of ~11 μm in tissue, −93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery‐powered device has a weight of 3 kg in a tablet format, enabling point‐of‐care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient‐centered diagnostic imaging workflow.
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy is presented. The instrument is enabled by a dedicated planar lightwave circuit (1.1 × 19.5 mm2 footprint) providing akinetic axial OCT scanning. The OCT engine (80 × 27 × 14 mm3 in volume), achieves ~11 μm of isotropic resolution in tissue, −93 dB sensitivity, 12 mm field of view, and 2.8 mm axial scanning range in air.</description><identifier>ISSN: 1864-063X</identifier><identifier>EISSN: 1864-0648</identifier><identifier>DOI: 10.1002/jbio.201800193</identifier><identifier>PMID: 29992726</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Butterflies & moths ; dermatology ; Diagnostic systems ; Field of view ; Integrated optics ; Medical imaging ; Microelectromechanical systems ; Microscopy ; Miniaturization ; multimodality imaging ; Optical Coherence Tomography ; Optics ; Scanning ; Skin ; Tomography ; Weight ; Workflow</subject><ispartof>Journal of biophotonics, 2018-10, Vol.11 (10), p.e201800193-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3733-eff4e72f7df8e0bd250c63ee10f2e5dde399a0b6fa4ddb4375b8a1292f703bbc3</citedby><cites>FETCH-LOGICAL-c3733-eff4e72f7df8e0bd250c63ee10f2e5dde399a0b6fa4ddb4375b8a1292f703bbc3</cites><orcidid>0000-0002-2081-6707</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbio.201800193$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbio.201800193$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29992726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sancho‐Durá, Juan</creatorcontrib><creatorcontrib>Zinoviev, Kirill</creatorcontrib><creatorcontrib>Lloret‐Soler, Juan</creatorcontrib><creatorcontrib>Rubio‐Guviernau, Jose Luis</creatorcontrib><creatorcontrib>Margallo‐Balbás, Eduardo</creatorcontrib><creatorcontrib>Drexler, Wolfgang</creatorcontrib><title>Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography</title><title>Journal of biophotonics</title><addtitle>J Biophotonics</addtitle><description>A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage Micro Electro‐Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm3, achieves an isotropic resolution of ~11 μm in tissue, −93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery‐powered device has a weight of 3 kg in a tablet format, enabling point‐of‐care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient‐centered diagnostic imaging workflow.
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy is presented. The instrument is enabled by a dedicated planar lightwave circuit (1.1 × 19.5 mm2 footprint) providing akinetic axial OCT scanning. The OCT engine (80 × 27 × 14 mm3 in volume), achieves ~11 μm of isotropic resolution in tissue, −93 dB sensitivity, 12 mm field of view, and 2.8 mm axial scanning range in air.</description><subject>Butterflies & moths</subject><subject>dermatology</subject><subject>Diagnostic systems</subject><subject>Field of view</subject><subject>Integrated optics</subject><subject>Medical imaging</subject><subject>Microelectromechanical systems</subject><subject>Microscopy</subject><subject>Miniaturization</subject><subject>multimodality imaging</subject><subject>Optical Coherence Tomography</subject><subject>Optics</subject><subject>Scanning</subject><subject>Skin</subject><subject>Tomography</subject><subject>Weight</subject><subject>Workflow</subject><issn>1864-063X</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkb1uFDEUhS0EIiHQUiJLNDS7XNvz5xIiIEGR0oBEZ_nnetfLzHiwZxRtR8ED8Iw8CV5tWCQaGl_r-DtHVz6EPGewZgD89c6EuObAOgAmxQNyzrqmWkFTdQ9Pd_HljDzJeQfQgKjFY3LGpZS85c05-XGlR7fF3tFh6efw6_vPITrd0zDoTRg31MdEpxjGubxEXw6rE9L8NYzUBb0ZYw6ZGp3R0ThSXXScg6XFgJuk54M8FSEfRwm2cYsJR4t0jkMszLTdPyWPvO4zPrufF-Tz-3efLq9WN7cfri_f3KysaIVYofcVtty3zncIxvEabCMQGXiOtXMopNRgGq8r50wl2tp0mnFZHCCMseKCvDrmTil-WzDPagjZYt_rEeOSFYemE5WoK1nQl_-gu7iksWynOGMtVLUEUaj1kbIp5pzQqymVn0t7xUAd-lGHftSpn2J4cR-7mAHdCf9TSAHkEbgLPe7_E6c-vr2-_Rv-G9pcor0</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Sancho‐Durá, Juan</creator><creator>Zinoviev, Kirill</creator><creator>Lloret‐Soler, Juan</creator><creator>Rubio‐Guviernau, Jose Luis</creator><creator>Margallo‐Balbás, Eduardo</creator><creator>Drexler, Wolfgang</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2081-6707</orcidid></search><sort><creationdate>201810</creationdate><title>Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography</title><author>Sancho‐Durá, Juan ; Zinoviev, Kirill ; Lloret‐Soler, Juan ; Rubio‐Guviernau, Jose Luis ; Margallo‐Balbás, Eduardo ; Drexler, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3733-eff4e72f7df8e0bd250c63ee10f2e5dde399a0b6fa4ddb4375b8a1292f703bbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Butterflies & moths</topic><topic>dermatology</topic><topic>Diagnostic systems</topic><topic>Field of view</topic><topic>Integrated optics</topic><topic>Medical imaging</topic><topic>Microelectromechanical systems</topic><topic>Microscopy</topic><topic>Miniaturization</topic><topic>multimodality imaging</topic><topic>Optical Coherence Tomography</topic><topic>Optics</topic><topic>Scanning</topic><topic>Skin</topic><topic>Tomography</topic><topic>Weight</topic><topic>Workflow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sancho‐Durá, Juan</creatorcontrib><creatorcontrib>Zinoviev, Kirill</creatorcontrib><creatorcontrib>Lloret‐Soler, Juan</creatorcontrib><creatorcontrib>Rubio‐Guviernau, Jose Luis</creatorcontrib><creatorcontrib>Margallo‐Balbás, Eduardo</creatorcontrib><creatorcontrib>Drexler, Wolfgang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biophotonics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sancho‐Durá, Juan</au><au>Zinoviev, Kirill</au><au>Lloret‐Soler, Juan</au><au>Rubio‐Guviernau, Jose Luis</au><au>Margallo‐Balbás, Eduardo</au><au>Drexler, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography</atitle><jtitle>Journal of biophotonics</jtitle><addtitle>J Biophotonics</addtitle><date>2018-10</date><risdate>2018</risdate><volume>11</volume><issue>10</issue><spage>e201800193</spage><epage>n/a</epage><pages>e201800193-n/a</pages><issn>1864-063X</issn><eissn>1864-0648</eissn><abstract>A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage Micro Electro‐Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm3, achieves an isotropic resolution of ~11 μm in tissue, −93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery‐powered device has a weight of 3 kg in a tablet format, enabling point‐of‐care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient‐centered diagnostic imaging workflow.
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy is presented. The instrument is enabled by a dedicated planar lightwave circuit (1.1 × 19.5 mm2 footprint) providing akinetic axial OCT scanning. The OCT engine (80 × 27 × 14 mm3 in volume), achieves ~11 μm of isotropic resolution in tissue, −93 dB sensitivity, 12 mm field of view, and 2.8 mm axial scanning range in air.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><pmid>29992726</pmid><doi>10.1002/jbio.201800193</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2081-6707</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1864-063X |
| ispartof | Journal of biophotonics, 2018-10, Vol.11 (10), p.e201800193-n/a |
| issn | 1864-063X 1864-0648 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2068343549 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Butterflies & moths dermatology Diagnostic systems Field of view Integrated optics Medical imaging Microelectromechanical systems Microscopy Miniaturization multimodality imaging Optical Coherence Tomography Optics Scanning Skin Tomography Weight Workflow |
| title | Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T04%3A53%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Handheld%20multi%E2%80%90modal%20imaging%20for%20point%E2%80%90of%E2%80%90care%20skin%20diagnosis%20based%20on%20akinetic%20integrated%20optics%20optical%20coherence%20tomography&rft.jtitle=Journal%20of%20biophotonics&rft.au=Sancho%E2%80%90Dur%C3%A1,%20Juan&rft.date=2018-10&rft.volume=11&rft.issue=10&rft.spage=e201800193&rft.epage=n/a&rft.pages=e201800193-n/a&rft.issn=1864-063X&rft.eissn=1864-0648&rft_id=info:doi/10.1002/jbio.201800193&rft_dat=%3Cproquest_cross%3E2117045903%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2117045903&rft_id=info:pmid/29992726&rfr_iscdi=true |