Hydrogen peroxide modulates redox status, energy metabolism, and gene expression in a dose‐ and time‐dependent manner in rat liver

Aim The aim of this study was to investigate the effect of three different hydrogen peroxide (H2O2) levels on blood and liver oxidative status, energy metabolites, and gene expression in male albino rats at two time intervals (2 and 4 weeks). Methods A total of 32 rats were divided into four groups....

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2018-10, Vol.32 (10), p.e22199-N/A
Hauptverfasser:	Ahmed‐Farid, Omar A., Rizk, Hanan A., Shehata, Ahmed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Antioxidants Aspartate Aminotransferases - blood Biomarkers - metabolism cell energy Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dose-Response Relationship, Drug Drinking water Energy metabolism Energy Metabolism - drug effects Gene expression Gene Expression - drug effects Glutathione Peroxidase - metabolism Hydrogen Hydrogen peroxide Hydrogen Peroxide - administration & dosage Hydrogen Peroxide - toxicity Liver Liver - drug effects Liver - enzymology Liver - metabolism Male Malondialdehyde - metabolism Metabolism Metabolites NF-E2-Related Factor 2 - metabolism Nrf2 pathway NRF2 protein Oxidation-Reduction Oxidative Stress oxidative stress model Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Rodents Time dependence Time Factors
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