Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: implications for migraine

Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the n...

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Veröffentlicht in:	Pain (Amsterdam) 2018-11, Vol.159 (11), p.2306-2317
Hauptverfasser:	Rea, Brandon J., Wattiez, Anne-Sophie, Waite, Jayme S., Castonguay, William C., Schmidt, Chantel M., Fairbanks, Aaron M., Robertson, Bennett R., Brown, Cameron J., Mason, Bianca N., Moldovan-Loomis, Maria-Cristina, Garcia-Martinez, Leon F., Poolman, Pieter, Ledolter, Johannes, Kardon, Randy H., Sowers, Levi P., Russo, Andrew F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antibodies - therapeutic use Calcitonin Gene-Related Peptide - immunology Calcitonin Gene-Related Peptide - toxicity Disease Models, Animal Facial Pain - chemically induced Facial Pain - drug therapy Injections, Intraperitoneal Locomotion - drug effects Meloxicam Mice Mice, Inbred C57BL Pain - chemically induced Pain - drug therapy Pain - physiopathology Serotonin 5-HT1 Receptor Agonists - therapeutic use Sumatriptan - therapeutic use
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