Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers
The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality. Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyre...
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| Veröffentlicht in: | International archives of occupational and environmental health 2006-05, Vol.79 (5), p.349-356 |
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| creator | HSU, Ping-Chi CHEN, I.-Yueh WU, Ming-Tsang PAN, Chih-Hong WU, Kuen-Yuh PAN, Min-Hsiung CHEN, Jenq-Renn CHEN, Cheng-Jung CHANG-CHIEN, Guo-Ping HSU, Chang-Hung LIU, Chiu-Shong |
| description | The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality.
Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined.
TO workers had significantly higher ambient PAHs exposure (3,436.1+/-3,411.0 vs. 1,123.1+/-1,829.3 ng/m3, P < 0.01), urinary 1-OHP levels (207.8+/-176.4 vs. 54.0+/-44.8 microg/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alphaT) and percentage of sperm with increased DNA denaturation (COMP alphaT) levels than SO workers (246.2+/-49.5 vs. 198.1+/-30.3 for alphaT; 34.8+/-14.4 vs. 19.3+/-13.9% for COMP alphaT, P < 0.05). There was a positive correlation between urinary 1-OHP and alphaT, COMP alphaT, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alphaT, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology.
A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction. |
| doi_str_mv | 10.1007/s00420-005-0066-3 |
| format | Article |
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Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined.
TO workers had significantly higher ambient PAHs exposure (3,436.1+/-3,411.0 vs. 1,123.1+/-1,829.3 ng/m3, P < 0.01), urinary 1-OHP levels (207.8+/-176.4 vs. 54.0+/-44.8 microg/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alphaT) and percentage of sperm with increased DNA denaturation (COMP alphaT) levels than SO workers (246.2+/-49.5 vs. 198.1+/-30.3 for alphaT; 34.8+/-14.4 vs. 19.3+/-13.9% for COMP alphaT, P < 0.05). There was a positive correlation between urinary 1-OHP and alphaT, COMP alphaT, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alphaT, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology.
A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-005-0066-3</identifier><identifier>PMID: 16362321</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Cigarettes ; Coke ; Deoxyribonucleic acid ; DNA ; DNA Damage - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Occupational Exposure ; Polycyclic Aromatic Hydrocarbons ; Smoking - genetics ; Spermatozoa - growth & development ; Spermatozoa - pathology ; Taiwan ; Tobacco, tobacco smoking ; Toxicology ; Tumors</subject><ispartof>International archives of occupational and environmental health, 2006-05, Vol.79 (5), p.349-356</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-14fd2e6901eceb298438a8072aeeae3c96f555bedfaa861d378b17af0ef0c3dd3</citedby><cites>FETCH-LOGICAL-c418t-14fd2e6901eceb298438a8072aeeae3c96f555bedfaa861d378b17af0ef0c3dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17736361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16362321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HSU, Ping-Chi</creatorcontrib><creatorcontrib>CHEN, I.-Yueh</creatorcontrib><creatorcontrib>WU, Ming-Tsang</creatorcontrib><creatorcontrib>PAN, Chih-Hong</creatorcontrib><creatorcontrib>WU, Kuen-Yuh</creatorcontrib><creatorcontrib>PAN, Min-Hsiung</creatorcontrib><creatorcontrib>CHEN, Jenq-Renn</creatorcontrib><creatorcontrib>CHEN, Cheng-Jung</creatorcontrib><creatorcontrib>CHANG-CHIEN, Guo-Ping</creatorcontrib><creatorcontrib>HSU, Chang-Hung</creatorcontrib><creatorcontrib>LIU, Chiu-Shong</creatorcontrib><title>Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><description>The aim was to determine whether occupational exposure to polycyclic aromatic hydrocarbons (PAHs) in men has adverse effect on semen quality.
Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined.
TO workers had significantly higher ambient PAHs exposure (3,436.1+/-3,411.0 vs. 1,123.1+/-1,829.3 ng/m3, P < 0.01), urinary 1-OHP levels (207.8+/-176.4 vs. 54.0+/-44.8 microg/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alphaT) and percentage of sperm with increased DNA denaturation (COMP alphaT) levels than SO workers (246.2+/-49.5 vs. 198.1+/-30.3 for alphaT; 34.8+/-14.4 vs. 19.3+/-13.9% for COMP alphaT, P < 0.05). There was a positive correlation between urinary 1-OHP and alphaT, COMP alphaT, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alphaT, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology.
A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Cigarettes</subject><subject>Coke</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Polycyclic Aromatic Hydrocarbons</subject><subject>Smoking - genetics</subject><subject>Spermatozoa - growth & development</subject><subject>Spermatozoa - pathology</subject><subject>Taiwan</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Tumors</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1v1DAQhi0EokvhB3BBFhLc0s7YXjs5VuVTqugBOJuJM6Fpk3ixs6323-PVrlSJEwfL1vh5R2M_QrxGOEMAd54BjIIKYF2WtZV-IlZotKpQGftUrECbcosaT8SLnG8B0Fmnn4sTtNoqrXAlfn3fcJrkh28XsqOJfrMMMSUeaeEsH4blRm7iuAu7MA5BUooTLeVws-tSDJTaOGfZDqWa7jjJYS7pO67iPc_yIe5r-aV41tOY-dVxPxU_P338cfmlurr-_PXy4qoKBuulQtN3im0DyIFb1dRG11SDU8RMrENj-_V63XLXE9UWO-3qFh31wD0E3XX6VLw_9N2k-GfLefHTkAOPI80ct9krsDWoRv0P6BpjbAHf_gPexm2ayyO8RV2mUUoXCA9QSDHnxL3fpKF8x84j-L0kf5DkiyS_l-T3mTfHxtt24u4xcbRSgHdHgHKgsU80hyE_cs7pgqL-C6oNmnk</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>HSU, Ping-Chi</creator><creator>CHEN, I.-Yueh</creator><creator>WU, Ming-Tsang</creator><creator>PAN, Chih-Hong</creator><creator>WU, Kuen-Yuh</creator><creator>PAN, Min-Hsiung</creator><creator>CHEN, Jenq-Renn</creator><creator>CHEN, Cheng-Jung</creator><creator>CHANG-CHIEN, Guo-Ping</creator><creator>HSU, Chang-Hung</creator><creator>LIU, Chiu-Shong</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7TV</scope><scope>7U2</scope></search><sort><creationdate>20060501</creationdate><title>Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers</title><author>HSU, Ping-Chi ; CHEN, I.-Yueh ; WU, Ming-Tsang ; PAN, Chih-Hong ; WU, Kuen-Yuh ; PAN, Min-Hsiung ; CHEN, Jenq-Renn ; CHEN, Cheng-Jung ; CHANG-CHIEN, Guo-Ping ; HSU, Chang-Hung ; LIU, Chiu-Shong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-14fd2e6901eceb298438a8072aeeae3c96f555bedfaa861d378b17af0ef0c3dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Cigarettes</topic><topic>Coke</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Damage - 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Forty-eight coke-oven workers, including 16 topside-oven (TO) workers and 32 sideoven (SO) workers, were studied. Ambient PAHs exposure, urinary 1-hydroxypyrene (1-OHP) levels, and parameters of semen quality were determined.
TO workers had significantly higher ambient PAHs exposure (3,436.1+/-3,411.0 vs. 1,123.1+/-1,829.3 ng/m3, P < 0.01), urinary 1-OHP levels (207.8+/-176.4 vs. 54.0+/-44.8 microg/g, P < 0.001), frequency of oligospermia (18.8 vs. 0%, P < 0.05), and morphological abnormality in sperm (32.3 vs. 14.6%, P < 0.01) than SO workers. Among cigarette smokers, TO workers had significantly higher rates of DNA denaturation in spermatozoa (alphaT) and percentage of sperm with increased DNA denaturation (COMP alphaT) levels than SO workers (246.2+/-49.5 vs. 198.1+/-30.3 for alphaT; 34.8+/-14.4 vs. 19.3+/-13.9% for COMP alphaT, P < 0.05). There was a positive correlation between urinary 1-OHP and alphaT, COMP alphaT, and abnormal sperm morphology and a tenfold increase in urinary 1-OHP associated with a 2.35-fold increase in alphaT, as well as a 1.07-fold increase in percentage of sperm with abnormal morphology.
A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16362321</pmid><doi>10.1007/s00420-005-0066-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | International archives of occupational and environmental health, 2006-05, Vol.79 (5), p.349-356 |
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| subjects | Adult Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cigarettes Coke Deoxyribonucleic acid DNA DNA Damage - genetics Humans Male Medical sciences Middle Aged Occupational Exposure Polycyclic Aromatic Hydrocarbons Smoking - genetics Spermatozoa - growth & development Spermatozoa - pathology Taiwan Tobacco, tobacco smoking Toxicology Tumors |
| title | Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers |
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