The mouse autonomic nervous system modulates inflammation and epithelial renewal after corneal abrasion through the activation of distinct local macrophages

Inflammation and reepithelialization after corneal abrasion are critical for the rapid restoration of vision and the prevention of microbial infections. However, the endogenous regulatory mechanisms are not completely understood. Here we report that the manipulation of autonomic nervous system (ANS)...

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Veröffentlicht in:	Mucosal immunology 2018-09, Vol.11 (5), p.1496-1511
Hauptverfasser:	Xue, Yunxia, He, Jingxin, Xiao, Chengju, Guo, Yonglong, Fu, Ting, Liu, Jun, Lin, Cuipei, Wu, Mingjuan, Yang, Yabing, Dong, Dong, Pan, Hongwei, Xia, Chaoyong, Ren, Li, Li, Zhijie
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrasion Adrenergic beta-2 Receptor Agonists - pharmacology Adrenergic receptors Agonists Allergology Animals Antibodies Autonomic nervous system Biomedical and Life Sciences Biomedicine CC chemokine receptors CCR2 protein Cell activation Cornea Cornea - drug effects Cornea - metabolism Cornea - physiopathology Corneal Injuries - drug therapy Corneal Injuries - metabolism Corneal Injuries - physiopathology Cytokines Cytokines - metabolism Disease Models, Animal Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - physiology Gastroenterology Immunology Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - physiopathology Leukocytes (neutrophilic) Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - physiology Male Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Nervous system Neutrophils Neutrophils - drug effects Neutrophils - metabolism Parasympathetic nervous system Parasympathetic Nervous System - physiology Receptors, CCR2 - metabolism Receptors, IgG - metabolism Sympathetic nerves Wound healing Wound Healing - drug effects Wound Healing - physiology
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