A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung
The aim was to investigate the clinicopathological characteristics, diagnosis, and prognosis of sarcomatoid carcinoma of the lung. We reviewed 114 cases of sarcomatoid carcinoma of the lung in patients that were admitted to the First Affiliated Hospital of Zhengzhou University and Anyang Tumor Hospi...
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| Veröffentlicht in: | Clinical and experimental medicine 2018-11, Vol.18 (4), p.555-562 |
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| creator | Hou, Junna Xing, Lihua Yuan, Yufen |
| description | The aim was to investigate the clinicopathological characteristics, diagnosis, and prognosis of sarcomatoid carcinoma of the lung. We reviewed 114 cases of sarcomatoid carcinoma of the lung in patients that were admitted to the First Affiliated Hospital of Zhengzhou University and Anyang Tumor Hospital from January 2009 to March 2018. We analyzed the clinical characteristics, immunohistochemical profiles, treatments, and overall survival of the patients. The patient population included 88 men and 26 women. Median patient age was 65 years (range 37–88 years), and the gender ratio (M/F) was 3.4:1. Median survival was 3.5 months (range 0.5–60 months). Univariate analysis showed that tumor location, tumor size, M stage, TNM stage, chemotherapy, and surgery were all prognostic factors for survival (
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| doi_str_mv | 10.1007/s10238-018-0517-2 |
| format | Article |
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P
< 0.05). We found that T stage, surgery, and chemotherapy were independent prognostic factors for sarcomatoid carcinoma (
P
< 0.05). Pulmonary sarcomatoid carcinoma is a rare tumor with a poor prognosis. Patients with smaller T stage, complete resection, and chemotherapy exhibited a better prognosis. Early diagnosis and early treatment are important to improve the prognosis of these patients.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-018-0517-2</identifier><identifier>PMID: 29987681</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinosarcoma - diagnosis ; Carcinosarcoma - pathology ; Carcinosarcoma - therapy ; Chemotherapy ; Diagnosis ; Drug Therapy ; Female ; Hematology ; Humans ; Internal Medicine ; Lung cancer ; Lung carcinoma ; Lung Neoplasms - diagnosis ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Oncology ; Original Article ; Patients ; Prognosis ; Pulmonary Surgical Procedures ; Retrospective Studies ; Surgery ; Survival ; Survival Analysis ; Tumor Burden</subject><ispartof>Clinical and experimental medicine, 2018-11, Vol.18 (4), p.555-562</ispartof><rights>Springer Nature Switzerland AG 2018</rights><rights>Clinical and Experimental Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9ff1247264a6caf235634901f9bd35bc1f2dd15516c371aeca601ea8a92fa9c23</citedby><cites>FETCH-LOGICAL-c372t-9ff1247264a6caf235634901f9bd35bc1f2dd15516c371aeca601ea8a92fa9c23</cites><orcidid>0000-0001-6974-8568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10238-018-0517-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10238-018-0517-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29987681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Junna</creatorcontrib><creatorcontrib>Xing, Lihua</creatorcontrib><creatorcontrib>Yuan, Yufen</creatorcontrib><title>A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><addtitle>Clin Exp Med</addtitle><description>The aim was to investigate the clinicopathological characteristics, diagnosis, and prognosis of sarcomatoid carcinoma of the lung. We reviewed 114 cases of sarcomatoid carcinoma of the lung in patients that were admitted to the First Affiliated Hospital of Zhengzhou University and Anyang Tumor Hospital from January 2009 to March 2018. We analyzed the clinical characteristics, immunohistochemical profiles, treatments, and overall survival of the patients. The patient population included 88 men and 26 women. Median patient age was 65 years (range 37–88 years), and the gender ratio (M/F) was 3.4:1. Median survival was 3.5 months (range 0.5–60 months). Univariate analysis showed that tumor location, tumor size, M stage, TNM stage, chemotherapy, and surgery were all prognostic factors for survival (
P
< 0.05). We found that T stage, surgery, and chemotherapy were independent prognostic factors for sarcomatoid carcinoma (
P
< 0.05). Pulmonary sarcomatoid carcinoma is a rare tumor with a poor prognosis. Patients with smaller T stage, complete resection, and chemotherapy exhibited a better prognosis. Early diagnosis and early treatment are important to improve the prognosis of these patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinosarcoma - diagnosis</subject><subject>Carcinosarcoma - pathology</subject><subject>Carcinosarcoma - therapy</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Drug Therapy</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Pulmonary Surgical Procedures</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Tumor Burden</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMtOAyEUhonR2Fp9ADdmEjduRjkwMLBsmnpJmrjRNaEM1GnmUmFm0beX6VRNTFwQOJzv_IQPoWvA94Bx_hAAEypSDHExyFNygqbAJKSSEXF6PAsh8QRdhLDFGJig-BxNiJQi5wKmaDlPTFU2pdFVohtd7UMZktYlAFlidLCHImhv2lp3bVnES2_KJlZDo_uwSdU3m0t05nQV7NVxn6H3x-Xb4jldvT69LOar1NCcdKl0DkiWE55pbrQjlHGaSQxOrgvK1gYcKQpgDHjkQVujOQarhZbEaWkInaG7MXfn28_ehk7VZTC2qnRj2z4ognkuBKcMInr7B922vY8_PFBc5JDRIRBGyvg2BG-d2vmy1n6vAKvBsRodq-hYDY7VMHNzTO7XtS1-Jr6lRoCMQIitZmP979P_p34B_yyEbg</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Hou, Junna</creator><creator>Xing, Lihua</creator><creator>Yuan, Yufen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6974-8568</orcidid></search><sort><creationdate>20181101</creationdate><title>A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung</title><author>Hou, Junna ; Xing, Lihua ; Yuan, Yufen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9ff1247264a6caf235634901f9bd35bc1f2dd15516c371aeca601ea8a92fa9c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinosarcoma - diagnosis</topic><topic>Carcinosarcoma - pathology</topic><topic>Carcinosarcoma - therapy</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Drug Therapy</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Pulmonary Surgical Procedures</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Junna</creatorcontrib><creatorcontrib>Xing, Lihua</creatorcontrib><creatorcontrib>Yuan, Yufen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Junna</au><au>Xing, Lihua</au><au>Yuan, Yufen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung</atitle><jtitle>Clinical and experimental medicine</jtitle><stitle>Clin Exp Med</stitle><addtitle>Clin Exp Med</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>18</volume><issue>4</issue><spage>555</spage><epage>562</epage><pages>555-562</pages><issn>1591-8890</issn><eissn>1591-9528</eissn><abstract>The aim was to investigate the clinicopathological characteristics, diagnosis, and prognosis of sarcomatoid carcinoma of the lung. We reviewed 114 cases of sarcomatoid carcinoma of the lung in patients that were admitted to the First Affiliated Hospital of Zhengzhou University and Anyang Tumor Hospital from January 2009 to March 2018. We analyzed the clinical characteristics, immunohistochemical profiles, treatments, and overall survival of the patients. The patient population included 88 men and 26 women. Median patient age was 65 years (range 37–88 years), and the gender ratio (M/F) was 3.4:1. Median survival was 3.5 months (range 0.5–60 months). Univariate analysis showed that tumor location, tumor size, M stage, TNM stage, chemotherapy, and surgery were all prognostic factors for survival (
P
< 0.05). We found that T stage, surgery, and chemotherapy were independent prognostic factors for sarcomatoid carcinoma (
P
< 0.05). Pulmonary sarcomatoid carcinoma is a rare tumor with a poor prognosis. Patients with smaller T stage, complete resection, and chemotherapy exhibited a better prognosis. Early diagnosis and early treatment are important to improve the prognosis of these patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29987681</pmid><doi>10.1007/s10238-018-0517-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6974-8568</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinosarcoma - diagnosis Carcinosarcoma - pathology Carcinosarcoma - therapy Chemotherapy Diagnosis Drug Therapy Female Hematology Humans Internal Medicine Lung cancer Lung carcinoma Lung Neoplasms - diagnosis Lung Neoplasms - pathology Lung Neoplasms - therapy Male Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Original Article Patients Prognosis Pulmonary Surgical Procedures Retrospective Studies Surgery Survival Survival Analysis Tumor Burden |
| title | A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung |
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