Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury
Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in Staphylococcus aureus -induced endometritis. Histopathological observations and myelo...
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| Veröffentlicht in: | Inflammation 2018-10, Vol.41 (5), p.1702-1716 |
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| creator | Wang, Xiaoyan Yuan, Ting Yin, Nannan Ma, Xiaofei Zhang, Zhenbiao Zhu, Zhe Shaukat, Aftab Deng, Ganzhen |
| description | Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in
Staphylococcus aureus
-induced endometritis. Histopathological observations and myeloperoxidase (MPO) activity showed that luteoloside could protect the uterus from
S. aureus
-induced damage and ameliorate the infiltration of inflammatory cells. Quantitative PCR (qPCR) and ELISA analysis also revealed that luteoloside could decrease the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and increase the expression of the anti-inflammatory cytokine IL-10 both
in vivo
and
in vitro
. However, western blot analysis revealed that luteoloside inhibited the expression of TLR2 and IL-8 and inhibited the phosphorylation of IκBα and NF-κB p65. Moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (EECs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by
S. aureus
. Furthermore, this study showed that luteoloside inhibited the expression of Bax but increased the expression of Bcl-2. These results indicate that luteoloside has anti-inflammatory properties by inhibiting the TLR2 and NF-κB signaling pathways and plays an anti-apoptotic role in
S. aureus
-induced endometritis, which may be valuable for the clinical treatment of
S. aureus
-induced inflammation. |
| doi_str_mv | 10.1007/s10753-018-0814-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2067885793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2067885793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-9a1a787ebd9623f56958c4818afb4e345bfdb120805f9d504d0976e51a3896d3</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVpaTYfP6CXYuilh6gdWdbXMYS0WVhIoelZyJLc7GJbrj4O--8js2kLhZ4GZp5552VehN4R-EQAxOdEQDCKgUgMknRYvEIbwgTFLRP8NdoA5YCpUuIMnad0AACpJH2LzlqlpOgk2aBhV7IPY0h755tvMWRvc2ryk29-ZB9LaoYYpuZ7NsvTcQw2WFt7pkRfEt7Orljvmu08jGaaTN6H-bq5WcKSq166bsy8Dg8lHi_Rm8GMyV-91Av0-OXu8fYe7x6-bm9vdthS0WasDDFCCt87xVs6MK6YtNWnNEPfedqxfnA9aUECG5Rj0DlQgntGDJWKO3qBPp5klxh-FZ-ynvbJ-nE0sw8l6Ra4kJIJRSv64R_0EEqcq7mV4lJw4CtFTpSNIaXoB73E_WTiURPQawb6lIGuGeg1Ay3qzvsX5dJP3v3Z-P30CrQnINXR_NPHv6f_r_oMRbSR3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2066876063</pqid></control><display><type>article</type><title>Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Xiaoyan ; Yuan, Ting ; Yin, Nannan ; Ma, Xiaofei ; Zhang, Zhenbiao ; Zhu, Zhe ; Shaukat, Aftab ; Deng, Ganzhen</creator><creatorcontrib>Wang, Xiaoyan ; Yuan, Ting ; Yin, Nannan ; Ma, Xiaofei ; Zhang, Zhenbiao ; Zhu, Zhe ; Shaukat, Aftab ; Deng, Ganzhen</creatorcontrib><description>Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in
Staphylococcus aureus
-induced endometritis. Histopathological observations and myeloperoxidase (MPO) activity showed that luteoloside could protect the uterus from
S. aureus
-induced damage and ameliorate the infiltration of inflammatory cells. Quantitative PCR (qPCR) and ELISA analysis also revealed that luteoloside could decrease the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and increase the expression of the anti-inflammatory cytokine IL-10 both
in vivo
and
in vitro
. However, western blot analysis revealed that luteoloside inhibited the expression of TLR2 and IL-8 and inhibited the phosphorylation of IκBα and NF-κB p65. Moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (EECs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by
S. aureus
. Furthermore, this study showed that luteoloside inhibited the expression of Bax but increased the expression of Bcl-2. These results indicate that luteoloside has anti-inflammatory properties by inhibiting the TLR2 and NF-κB signaling pathways and plays an anti-apoptotic role in
S. aureus
-induced endometritis, which may be valuable for the clinical treatment of
S. aureus
-induced inflammation.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-018-0814-7</identifier><identifier>PMID: 29987481</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anti-inflammatory agents ; Apoptosis ; Apoptosis - drug effects ; Bcl-2 protein ; Biomedical and Life Sciences ; Biomedicine ; Caspase ; Caspase-3 ; Cytokines - drug effects ; Cytokines - metabolism ; Endometritis ; Endometritis - drug therapy ; Endometritis - microbiology ; Endometrium ; Enzyme-linked immunosorbent assay ; Epithelial cells ; Female ; Glucosides - pharmacology ; Glucosides - therapeutic use ; Humans ; Immunology ; Inflammation ; Inflammation - drug therapy ; Inflammation - microbiology ; Interleukin 10 ; Interleukin 6 ; Interleukin 8 ; Internal Medicine ; Luteolin - pharmacology ; Luteolin - therapeutic use ; NF-kappa B - drug effects ; NF-kappa B - metabolism ; NF-κB protein ; Original Article ; p53 Protein ; Pathology ; Peroxidase ; Pharmacology/Toxicology ; Phosphorylation ; Protective Agents - therapeutic use ; Rheumatology ; Staphylococcus aureus ; Staphylococcus aureus - pathogenicity ; TLR2 protein ; Toll-Like Receptor 2 - drug effects ; Toll-Like Receptor 2 - metabolism ; Toll-like receptors ; Tumor necrosis factor-α ; Uterus ; Uterus - injuries ; Uterus - microbiology ; Uterus - pathology</subject><ispartof>Inflammation, 2018-10, Vol.41 (5), p.1702-1716</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Inflammation is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9a1a787ebd9623f56958c4818afb4e345bfdb120805f9d504d0976e51a3896d3</citedby><cites>FETCH-LOGICAL-c372t-9a1a787ebd9623f56958c4818afb4e345bfdb120805f9d504d0976e51a3896d3</cites><orcidid>0000-0001-8190-0040</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-018-0814-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-018-0814-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29987481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaoyan</creatorcontrib><creatorcontrib>Yuan, Ting</creatorcontrib><creatorcontrib>Yin, Nannan</creatorcontrib><creatorcontrib>Ma, Xiaofei</creatorcontrib><creatorcontrib>Zhang, Zhenbiao</creatorcontrib><creatorcontrib>Zhu, Zhe</creatorcontrib><creatorcontrib>Shaukat, Aftab</creatorcontrib><creatorcontrib>Deng, Ganzhen</creatorcontrib><title>Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in
Staphylococcus aureus
-induced endometritis. Histopathological observations and myeloperoxidase (MPO) activity showed that luteoloside could protect the uterus from
S. aureus
-induced damage and ameliorate the infiltration of inflammatory cells. Quantitative PCR (qPCR) and ELISA analysis also revealed that luteoloside could decrease the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and increase the expression of the anti-inflammatory cytokine IL-10 both
in vivo
and
in vitro
. However, western blot analysis revealed that luteoloside inhibited the expression of TLR2 and IL-8 and inhibited the phosphorylation of IκBα and NF-κB p65. Moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (EECs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by
S. aureus
. Furthermore, this study showed that luteoloside inhibited the expression of Bax but increased the expression of Bcl-2. These results indicate that luteoloside has anti-inflammatory properties by inhibiting the TLR2 and NF-κB signaling pathways and plays an anti-apoptotic role in
S. aureus
-induced endometritis, which may be valuable for the clinical treatment of
S. aureus
-induced inflammation.</description><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bcl-2 protein</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cytokines - drug effects</subject><subject>Cytokines - metabolism</subject><subject>Endometritis</subject><subject>Endometritis - drug therapy</subject><subject>Endometritis - microbiology</subject><subject>Endometrium</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epithelial cells</subject><subject>Female</subject><subject>Glucosides - pharmacology</subject><subject>Glucosides - therapeutic use</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - microbiology</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Internal Medicine</subject><subject>Luteolin - pharmacology</subject><subject>Luteolin - therapeutic use</subject><subject>NF-kappa B - drug effects</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Original Article</subject><subject>p53 Protein</subject><subject>Pathology</subject><subject>Peroxidase</subject><subject>Pharmacology/Toxicology</subject><subject>Phosphorylation</subject><subject>Protective Agents - therapeutic use</subject><subject>Rheumatology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - pathogenicity</subject><subject>TLR2 protein</subject><subject>Toll-Like Receptor 2 - drug effects</subject><subject>Toll-Like Receptor 2 - metabolism</subject><subject>Toll-like receptors</subject><subject>Tumor necrosis factor-α</subject><subject>Uterus</subject><subject>Uterus - injuries</subject><subject>Uterus - microbiology</subject><subject>Uterus - pathology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1r3DAQhkVpaTYfP6CXYuilh6gdWdbXMYS0WVhIoelZyJLc7GJbrj4O--8js2kLhZ4GZp5552VehN4R-EQAxOdEQDCKgUgMknRYvEIbwgTFLRP8NdoA5YCpUuIMnad0AACpJH2LzlqlpOgk2aBhV7IPY0h755tvMWRvc2ryk29-ZB9LaoYYpuZ7NsvTcQw2WFt7pkRfEt7Orljvmu08jGaaTN6H-bq5WcKSq166bsy8Dg8lHi_Rm8GMyV-91Av0-OXu8fYe7x6-bm9vdthS0WasDDFCCt87xVs6MK6YtNWnNEPfedqxfnA9aUECG5Rj0DlQgntGDJWKO3qBPp5klxh-FZ-ynvbJ-nE0sw8l6Ra4kJIJRSv64R_0EEqcq7mV4lJw4CtFTpSNIaXoB73E_WTiURPQawb6lIGuGeg1Ay3qzvsX5dJP3v3Z-P30CrQnINXR_NPHv6f_r_oMRbSR3w</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Wang, Xiaoyan</creator><creator>Yuan, Ting</creator><creator>Yin, Nannan</creator><creator>Ma, Xiaofei</creator><creator>Zhang, Zhenbiao</creator><creator>Zhu, Zhe</creator><creator>Shaukat, Aftab</creator><creator>Deng, Ganzhen</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8190-0040</orcidid></search><sort><creationdate>20181001</creationdate><title>Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury</title><author>Wang, Xiaoyan ; Yuan, Ting ; Yin, Nannan ; Ma, Xiaofei ; Zhang, Zhenbiao ; Zhu, Zhe ; Shaukat, Aftab ; Deng, Ganzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9a1a787ebd9623f56958c4818afb4e345bfdb120805f9d504d0976e51a3896d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bcl-2 protein</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cytokines - drug effects</topic><topic>Cytokines - metabolism</topic><topic>Endometritis</topic><topic>Endometritis - drug therapy</topic><topic>Endometritis - microbiology</topic><topic>Endometrium</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epithelial cells</topic><topic>Female</topic><topic>Glucosides - pharmacology</topic><topic>Glucosides - therapeutic use</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - microbiology</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Internal Medicine</topic><topic>Luteolin - pharmacology</topic><topic>Luteolin - therapeutic use</topic><topic>NF-kappa B - drug effects</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Original Article</topic><topic>p53 Protein</topic><topic>Pathology</topic><topic>Peroxidase</topic><topic>Pharmacology/Toxicology</topic><topic>Phosphorylation</topic><topic>Protective Agents - therapeutic use</topic><topic>Rheumatology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - pathogenicity</topic><topic>TLR2 protein</topic><topic>Toll-Like Receptor 2 - drug effects</topic><topic>Toll-Like Receptor 2 - metabolism</topic><topic>Toll-like receptors</topic><topic>Tumor necrosis factor-α</topic><topic>Uterus</topic><topic>Uterus - injuries</topic><topic>Uterus - microbiology</topic><topic>Uterus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaoyan</creatorcontrib><creatorcontrib>Yuan, Ting</creatorcontrib><creatorcontrib>Yin, Nannan</creatorcontrib><creatorcontrib>Ma, Xiaofei</creatorcontrib><creatorcontrib>Zhang, Zhenbiao</creatorcontrib><creatorcontrib>Zhu, Zhe</creatorcontrib><creatorcontrib>Shaukat, Aftab</creatorcontrib><creatorcontrib>Deng, Ganzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaoyan</au><au>Yuan, Ting</au><au>Yin, Nannan</au><au>Ma, Xiaofei</au><au>Zhang, Zhenbiao</au><au>Zhu, Zhe</au><au>Shaukat, Aftab</au><au>Deng, Ganzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>41</volume><issue>5</issue><spage>1702</spage><epage>1716</epage><pages>1702-1716</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Luteoloside is a flavonoid extracted from several natural herbs that exhibits anti-microbial and anti-inflammation properties. Our study mainly identified the anti-inflammatory mechanism of action of luteoloside in
Staphylococcus aureus
-induced endometritis. Histopathological observations and myeloperoxidase (MPO) activity showed that luteoloside could protect the uterus from
S. aureus
-induced damage and ameliorate the infiltration of inflammatory cells. Quantitative PCR (qPCR) and ELISA analysis also revealed that luteoloside could decrease the expression of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 and increase the expression of the anti-inflammatory cytokine IL-10 both
in vivo
and
in vitro
. However, western blot analysis revealed that luteoloside inhibited the expression of TLR2 and IL-8 and inhibited the phosphorylation of IκBα and NF-κB p65. Moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (EECs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by
S. aureus
. Furthermore, this study showed that luteoloside inhibited the expression of Bax but increased the expression of Bcl-2. These results indicate that luteoloside has anti-inflammatory properties by inhibiting the TLR2 and NF-κB signaling pathways and plays an anti-apoptotic role in
S. aureus
-induced endometritis, which may be valuable for the clinical treatment of
S. aureus
-induced inflammation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29987481</pmid><doi>10.1007/s10753-018-0814-7</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-8190-0040</orcidid></addata></record> |
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| ispartof | Inflammation, 2018-10, Vol.41 (5), p.1702-1716 |
| issn | 0360-3997 1573-2576 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Anti-inflammatory agents Apoptosis Apoptosis - drug effects Bcl-2 protein Biomedical and Life Sciences Biomedicine Caspase Caspase-3 Cytokines - drug effects Cytokines - metabolism Endometritis Endometritis - drug therapy Endometritis - microbiology Endometrium Enzyme-linked immunosorbent assay Epithelial cells Female Glucosides - pharmacology Glucosides - therapeutic use Humans Immunology Inflammation Inflammation - drug therapy Inflammation - microbiology Interleukin 10 Interleukin 6 Interleukin 8 Internal Medicine Luteolin - pharmacology Luteolin - therapeutic use NF-kappa B - drug effects NF-kappa B - metabolism NF-κB protein Original Article p53 Protein Pathology Peroxidase Pharmacology/Toxicology Phosphorylation Protective Agents - therapeutic use Rheumatology Staphylococcus aureus Staphylococcus aureus - pathogenicity TLR2 protein Toll-Like Receptor 2 - drug effects Toll-Like Receptor 2 - metabolism Toll-like receptors Tumor necrosis factor-α Uterus Uterus - injuries Uterus - microbiology Uterus - pathology |
| title | Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury |
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