Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis

: The aim of this study was to evaluate the effects of melatonin on the inflammatory response and hydroxyproline production in an experimental acute and chronic model of trinitrobenzene sulfonic (TNBS) acid‐induced colitis in Wistar rats. In the acute model, melatonin (0.5, 1, and 2 mg/kg, i.p.) wa...

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Veröffentlicht in:	Journal of pineal research 2006-01, Vol.40 (1), p.48-55
Hauptverfasser:	Marquez, Esther, Sánchez-Fidalgo, Susana, Calvo, Juan Ramón, Lastra, Catalina Alarcón la de, Motilva, Virginia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences colitis Colitis - chemically induced Colitis - drug therapy Colitis - prevention & control collagen Colon - pathology Disease Models, Animal Drug Administration Schedule fibrosis Fundamental and applied biological sciences. Psychology inflammation inflammatory bowel disease Intestinal Mucosa - pathology Male melatonin Melatonin - administration & dosage myeloperoxidase Peroxidase - metabolism Rats Rats, Wistar TNF-α Trinitrobenzenesulfonic Acid Tumor Necrosis Factor-alpha - biosynthesis Vertebrates: endocrinology
Online-Zugang:	Volltext
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