Estrogen-Induced Alterations in amh and dmrt1 Expression Signal for Disruption in Male Sexual Development in the Zebrafish

Dmrt1 and amh are genes involved in vertebrate sex differentiation. In this study, we cloned dmrt1 and amh cDNAs in zebrafish (Danio rerio) and investigated the effects of exposure to 17α-ethinylestradiol (EE2), during early life on their patterns of expression and impact on the subsequent gonadal p...

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Veröffentlicht in:	Environmental science & technology 2007-09, Vol.41 (17), p.6305-6310
Hauptverfasser:	Schulz, Rüdiger W, Bogerd, Jan, Male, Rune, Ball, Jonathan, Fenske, Martina, Olsen, Lisbeth C, Tyler, Charles R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animal, plant and microbial ecology Animals Anti-Mullerian Hormone - genetics Applied ecology Biological and medical sciences Cloning Danio rerio Ecotoxicology, biological effects of pollution Estrogens Estrogens - toxicity Fish Freshwater Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology General aspects Genotype & phenotype Germ Cells - cytology Gonads - drug effects Gonads - growth & development Male Males Phenotype Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Sexual Development - drug effects Sexual Development - physiology Time Factors Transcription Factors - genetics Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - physiology
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