Modulation of carcinogen bioavailability by immunisation with benzo[ a ]pyrene-conjugate vaccines

Abstract Benzo[ a ]pyrene (B[ a ]P) conjugate vaccines based on ovalbumin, tetanus toxoid and diphtheria toxoid (DT) as carrier proteins were developed to investigate the effect of specific antibodies on the bioavailability of this ubiquitous carcinogen and its metabolites. After metabolic activatio...

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Veröffentlicht in:	Vaccine 2009-06, Vol.27 (31), p.4142-4151
Hauptverfasser:	Grova, Nathalie, Prodhomme, Emmanuel J.F, Schellenberger, Mario T, Farinelle, Sophie, Muller, Claude P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Applied microbiology Benzo(a)pyrene - antagonists & inhibitors Benzo[ a]pyrene Binding sites Bioavailability Biological and medical sciences Biological Availability Carcinogenesis Carcinogens Carcinogens - antagonists & inhibitors Competition Cross Reactions Deoxyribonucleic acid DNA DNA repair Female Fundamental and applied biological sciences. Psychology Immune response Immunization Medical sciences Metabolism Metabolites Mice Mice, Inbred BALB C Microbiology Molecular weight Pharmacokinetics Proteins Specific antibodies Tumors Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate - immunology
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