Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

Abstract Biomaterial scaffolds are central to many regenerative strategies as they create a space for infiltration of host tissue and provide a platform to deliver growth factors and progenitor cells. However, biomaterial implantation results in an unavoidable inflammatory response, which can impair...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2016-02, Vol.80, p.11-19
Hauptverfasser:	Liu, Jeffrey M.H, Zhang, Jesse, Zhang, Xiaomin, Hlavaty, Kelan A, Ricci, Christine F, Leonard, Joshua N, Shea, Lonnie D, Gower, R. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science animal disease models Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use biobased products Biomaterials Biomedical materials blood glucose cell culture cell transplantation Cells, Cultured Chemokine CCL2 - immunology Cytokines Dentistry diabetes Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - therapy Drug Delivery Systems - methods epididymis immune response Immunoengineering Immunomodulation Immunomodulation - drug effects Infiltration inflammation interleukin-12 Interleukin-12 - immunology Islets of Langerhans Transplantation - methods Leukocyte leukocytes Male Mice Mice, Inbred C57BL Porosity porous media Regenerative Scaffold Scaffolds sowing stem cells Surgical implants tissue repair Tissue Scaffolds - chemistry transforming growth factor beta 1 Transforming Growth Factor beta1 - administration & dosage Transforming Growth Factor beta1 - therapeutic use Transplant Transplantation tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!