Mechanisms of RND multidrug efflux pumps

RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and pe...

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Veröffentlicht in:	Biochimica et biophysica acta 2009-05, Vol.1794 (5), p.769-781
Hauptverfasser:	Nikaido, Hiroshi, Takatsuka, Yumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	AcrA AcrB AcrD Bacterial Proteins - physiology Carrier Proteins - physiology Crystallography, X-Ray Disulfide cross-linking Drug Resistance, Bacterial - physiology Escherichia coli Escherichia coli Proteins - genetics Escherichia coli Proteins - physiology Kinetics Models, Molecular Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - physiology Mutagenesis, Site-Directed Mutation Phospholipids - metabolism Proton relay network Reconstitution TolC
Online-Zugang:	Volltext
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