Regiodivergent Synthesis of 1,3‐ and 1,4‐Enynes through Kinetically Favored Hydropalladation and Ligand‐Enforced Carbopalladation

Pd‐catalyzed hydroalkynylations were developed that involve ligand‐enabled regiodivergent addition of an alkyne to an allenamide, giving branched and linear products stereoselectively and facilitated by the neighboring amide group. Regioselectivity was achieved with the use of (o‐OMePh)3P and BrettP...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Angewandte Chemie International Edition 2018-07, Vol.57 (31), p.9930-9935
Hauptverfasser:	Pradhan, Tapas R., Kim, Hong Won, Park, Jin Kyoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Alkynes Carbohydrates carbopalladation diastereoselectivity divergent hydropalladation Ligands Regioselectivity Steroid hormones Steroids Vitamins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!