Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors

Background : The combination of topoisomerase I and II chemotherapeutic agents has shown promising preclinical synergistic effects in the treatment of high-grade malignant brain tumors such as high-grade gliomas and choroid plexus carcinomas. To confirm the effectiveness of this treatment combinatio...

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Veröffentlicht in:	Journal of neuro-oncology 2008, Vol.86 (2), p.175-181
Hauptverfasser:	Wagner, Sabine, Peters, Ove, Fels, Christin, Janssen, Gisela, Liebeskind, Anne-Kathrin, Sauerbrey, Axel, Suttorp, Meinolf, Hau, Peter, Wolff, Johannes E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain tumors Carcinoma Carcinoma - drug therapy Carcinoma - pathology Chemotherapy Child Child, Preschool Children Choroid plexus Choroid Plexus Neoplasms - drug therapy Choroid Plexus Neoplasms - pathology Clinical-Patient Studies Dermatitis Diarrhea Disease-Free Survival DNA topoisomerase Dosage Dose-Response Relationship, Drug Doxorubicin Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Drug Administration Schedule Drug Eruptions Glioblastoma - drug therapy Glioblastoma - pathology Hematologic Diseases - chemically induced Humans Intravenous administration Medicine Medicine & Public Health Neoplasm Recurrence, Local - drug therapy Neurology Oncology Patients Polyethylene Glycols - administration & dosage Recurrence Retrospective Studies Stomatitis Stomatitis - chemically induced Topotecan Topotecan - administration & dosage Toxicity Treatment Outcome Tumors
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