Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells

Abstract Methamphetamine (METH) is one of the most commonly abused drugs that may result in neurotoxic damage. Many lines of evidence have revealed that oxidative stress plays an important role in METH-induced neurotoxic effects. In a previous study, it was demonstrated in human neuroblastoma SH-SY5...

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Veröffentlicht in:	Toxicology (Amsterdam) 2008-04, Vol.246 (2), p.234-241
Hauptverfasser:	Wang, Sheng-Fan, Yen, Jiin-Cherng, Yin, Pen-Hui, Chi, Chin-Wen, Lee, Hsin-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - pharmacology Antioxidants - pharmacology Apoptosis - drug effects Biological and medical sciences Cell death Cell Line, Tumor Central Nervous System Stimulants - toxicity Emergency Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Flavonoids - pharmacology Humans Imidazoles - pharmacology JNK JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences Methamphetamine Methamphetamine - toxicity Neuroblastoma - drug therapy Neuroblastoma - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Pyridines - pharmacology Toxicology Vitamin E - pharmacology
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