Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A sub(2) as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

The GIVA phospholipase A sub(2) (PLA sub(2)) contains two domains: a calcium-binding domain (C2) and a catalytic domain. These domains are linked via a flexible tether. GIVA PLA sub(2) activity is Ca super(2+)-dependent in that calcium binding promotes protein docking to the phospholipid membrane. I...

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Veröffentlicht in:	The Journal of biological chemistry 2008-04, Vol.283 (15), p.9820-9827
Hauptverfasser:	Hsu, Yuan-Hao, Burke, John E, Stephens, Daren L, Deems, Raymond A, Li, Sheng, Asmus, Kyle M, Woods, Virgil LJr, Dennis, Edward A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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