Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters
Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen....
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2004, Vol.66(10), pp.1223-1228 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan)) Suzuki, M Yamaguchi, K Fujita, T Katsube, N |
| description | Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen. NE activity, and tissue myeloperoxidase (MPO) activity in the colitis control animals were significantly increased compared to the normal control ones. Either oral or subcutaneous treatment with ONO-6818 had significant inhibitory effects on the ulcer area, hemoglobin level and NE activity in the colonic lumen, but ONO-6818 did not have a significant inhibitory effect on tissue MPO activity. We conclude that NE is closely related to the development of inflammation in acetic acid-induced colitis in Syrian hamsters and that the condition is improved by the inhibition of NE. |
| doi_str_mv | 10.1292/jvms.66.1223 |
| format | Article |
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(Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan)) ; Suzuki, M ; Yamaguchi, K ; Fujita, T ; Katsube, N</creator><creatorcontrib>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan)) ; Suzuki, M ; Yamaguchi, K ; Fujita, T ; Katsube, N</creatorcontrib><description>Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen. NE activity, and tissue myeloperoxidase (MPO) activity in the colitis control animals were significantly increased compared to the normal control ones. Either oral or subcutaneous treatment with ONO-6818 had significant inhibitory effects on the ulcer area, hemoglobin level and NE activity in the colonic lumen, but ONO-6818 did not have a significant inhibitory effect on tissue MPO activity. We conclude that NE is closely related to the development of inflammation in acetic acid-induced colitis in Syrian hamsters and that the condition is improved by the inhibition of NE.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.66.1223</identifier><identifier>PMID: 15528853</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Acetic Acid - toxicity ; Animals ; COLITIS ; Colitis - chemically induced ; Colitis - drug therapy ; Cricetinae ; ENZYME INHIBITORS ; GRANULOCYTES ; HAMSTERS ; Hemoglobins - metabolism ; Leukocyte Elastase - metabolism ; Male ; Mesocricetus ; neutrophil elastase ; orally active inhibitor ; Oxadiazoles - blood ; Oxadiazoles - pharmacokinetics ; Oxadiazoles - therapeutic use ; Peroxidase - metabolism ; PROTEASES ; Pyrimidinones - blood ; Pyrimidinones - pharmacokinetics ; Pyrimidinones - therapeutic use ; Serpins - therapeutic use ; Syrian hamster</subject><ispartof>Journal of Veterinary Medical Science, 2004, Vol.66(10), pp.1223-1228</ispartof><rights>2004 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c715t-dad4a1b3772238e39c97850bb50ce07848e4574ce4c3d1f8eead6289655edbbc3</citedby><cites>FETCH-LOGICAL-c715t-dad4a1b3772238e39c97850bb50ce07848e4574ce4c3d1f8eead6289655edbbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15528853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan))</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Yamaguchi, K</creatorcontrib><creatorcontrib>Fujita, T</creatorcontrib><creatorcontrib>Katsube, N</creatorcontrib><title>Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen. NE activity, and tissue myeloperoxidase (MPO) activity in the colitis control animals were significantly increased compared to the normal control ones. Either oral or subcutaneous treatment with ONO-6818 had significant inhibitory effects on the ulcer area, hemoglobin level and NE activity in the colonic lumen, but ONO-6818 did not have a significant inhibitory effect on tissue MPO activity. We conclude that NE is closely related to the development of inflammation in acetic acid-induced colitis in Syrian hamsters and that the condition is improved by the inhibition of NE.</description><subject>Acetic Acid - toxicity</subject><subject>Animals</subject><subject>COLITIS</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Cricetinae</subject><subject>ENZYME INHIBITORS</subject><subject>GRANULOCYTES</subject><subject>HAMSTERS</subject><subject>Hemoglobins - metabolism</subject><subject>Leukocyte Elastase - metabolism</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>neutrophil elastase</subject><subject>orally active inhibitor</subject><subject>Oxadiazoles - blood</subject><subject>Oxadiazoles - pharmacokinetics</subject><subject>Oxadiazoles - therapeutic use</subject><subject>Peroxidase - metabolism</subject><subject>PROTEASES</subject><subject>Pyrimidinones - blood</subject><subject>Pyrimidinones - pharmacokinetics</subject><subject>Pyrimidinones - therapeutic use</subject><subject>Serpins - therapeutic use</subject><subject>Syrian hamster</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuLFDEQh4Mo7uzqzasSEBYFe03SeR5lWF8sjqCeQzpdvZ2hH2OSFva_N80Mu-DJSxVFfXxQ9UPoBSVXlBn2fv9nTFdSloHVj9CG1lxVitfmMdoQQ2WlmCBn6DylPSGMcmmeojMqBNNa1BsUrrsOfE547nDuAU-w5Dgf-jBgGFzKLgEOUx-akOeI3-y-7SqpqX6L5wk7Dzn40kJbmHbx0GI_DyGHVGb84y4GN-HejSlDTM_Qk84NCZ6f-gX69fH65_ZzdbP79GX74abyiopcta7ljja1UuUeDbXxRmlBmkYQD0RproELxT1wX7e00wCulUwbKQS0TePrC3R59B7i_HuBlO0YkodhcBPMS7KMSCkkV_8BcqOYXsHX_4D7eYlTOcKWf2qpjTKsUO-OlI9zShE6e4hhdPHOUmLXpOyalJXSrkkV_NVJujQjtA_wKZoCbI_AvqRwC_eAi-XpAzzYyKmu2vut7120MBXLy6Olc7N1tzEk-_U7I0QQwplU9V9gZq72</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan))</creator><creator>Suzuki, M</creator><creator>Yamaguchi, K</creator><creator>Fujita, T</creator><creator>Katsube, N</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7T5</scope></search><sort><creationdate>20041001</creationdate><title>Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters</title><author>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan)) ; Suzuki, M ; Yamaguchi, K ; Fujita, T ; Katsube, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c715t-dad4a1b3772238e39c97850bb50ce07848e4574ce4c3d1f8eead6289655edbbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetic Acid - toxicity</topic><topic>Animals</topic><topic>COLITIS</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Cricetinae</topic><topic>ENZYME INHIBITORS</topic><topic>GRANULOCYTES</topic><topic>HAMSTERS</topic><topic>Hemoglobins - metabolism</topic><topic>Leukocyte Elastase - metabolism</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>neutrophil elastase</topic><topic>orally active inhibitor</topic><topic>Oxadiazoles - blood</topic><topic>Oxadiazoles - pharmacokinetics</topic><topic>Oxadiazoles - therapeutic use</topic><topic>Peroxidase - metabolism</topic><topic>PROTEASES</topic><topic>Pyrimidinones - blood</topic><topic>Pyrimidinones - pharmacokinetics</topic><topic>Pyrimidinones - therapeutic use</topic><topic>Serpins - therapeutic use</topic><topic>Syrian hamster</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan))</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Yamaguchi, K</creatorcontrib><creatorcontrib>Fujita, T</creatorcontrib><creatorcontrib>Katsube, N</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Immunology Abstracts</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan))</au><au>Suzuki, M</au><au>Yamaguchi, K</au><au>Fujita, T</au><au>Katsube, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>66</volume><issue>10</issue><spage>1223</spage><epage>1228</epage><pages>1223-1228</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen. NE activity, and tissue myeloperoxidase (MPO) activity in the colitis control animals were significantly increased compared to the normal control ones. Either oral or subcutaneous treatment with ONO-6818 had significant inhibitory effects on the ulcer area, hemoglobin level and NE activity in the colonic lumen, but ONO-6818 did not have a significant inhibitory effect on tissue MPO activity. We conclude that NE is closely related to the development of inflammation in acetic acid-induced colitis in Syrian hamsters and that the condition is improved by the inhibition of NE.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>15528853</pmid><doi>10.1292/jvms.66.1223</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Acetic Acid - toxicity Animals COLITIS Colitis - chemically induced Colitis - drug therapy Cricetinae ENZYME INHIBITORS GRANULOCYTES HAMSTERS Hemoglobins - metabolism Leukocyte Elastase - metabolism Male Mesocricetus neutrophil elastase orally active inhibitor Oxadiazoles - blood Oxadiazoles - pharmacokinetics Oxadiazoles - therapeutic use Peroxidase - metabolism PROTEASES Pyrimidinones - blood Pyrimidinones - pharmacokinetics Pyrimidinones - therapeutic use Serpins - therapeutic use Syrian hamster |
| title | Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters |
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