Synthetic β‑Barrel by Metal-Induced Folding and Assembly
The de novo construction of repeat proteins has received much attention from biologists and chemists, yet that of a β-barrel structure, one of the most well-known classes, has not been accomplished to date. Here, we report the first chemical construction of a β-barrel tertiary structure with a pore...
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| Veröffentlicht in: | Journal of the American Chemical Society 2018-07, Vol.140 (28), p.8644-8647 |
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| container_issue | 28 |
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| container_title | Journal of the American Chemical Society |
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| creator | Yamagami, Motoya Sawada, Tomohisa Fujita, Makoto |
| description | The de novo construction of repeat proteins has received much attention from biologists and chemists, yet that of a β-barrel structure, one of the most well-known classes, has not been accomplished to date. Here, we report the first chemical construction of a β-barrel tertiary structure with a pore through a combination of peptide folding and metal-directed self-assembly. Coordination of zinc salts to an eight-residue peptide fragment bearing β-strand- and loop-forming sequences resulted in a β-barrel in which six-stranded cylindrical antiparallel β-sheets formed a hydrophobic pore with a specific shape. |
| doi_str_mv | 10.1021/jacs.8b04284 |
| format | Article |
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| source | American Chemical Society |
| title | Synthetic β‑Barrel by Metal-Induced Folding and Assembly |
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