Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

Receptor-operated Ca²⁺ entry (ROCE) and store-operated Ca²⁺ entry (SOCE) into cells are functions performed by all higher eukaryotic cells, and their impairment is life-threatening. The main molecular components of this pathway appear to be known. However, the molecular make-up of channels mediating...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-02, Vol.105 (8), p.2895-2900
Hauptverfasser:	Liao, Yanhong, Erxleben, Christian, Abramowitz, Joel, Flockerzi, Veit, Zhu, Michael Xi, Armstrong, David L, Birnbaumer, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins Biochemistry Biological Sciences Calcium Calcium - metabolism Calcium Channels - metabolism Cell Line Cell lines Cell membranes Electric current Electrophysiology Eukaryotes Gene Expression Regulation HEK293 cells Humans Ion channels Ion Transport - physiology Luminescent Proteins Membrane Proteins - metabolism Models, Biological Molecules Neoplasm Proteins - metabolism ORAI1 Protein Plasmids Receptors Signal transduction Stromal Interaction Molecule 1 Transfection TRPC Cation Channels - metabolism
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